{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:31:38Z","timestamp":1790346698469,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intensive care unit\u2013acquired weakness (ICU\u2010AW) is prevalent and adversely affects patient outcomes. Muscle strength progression and response to rehabilitation differ across ICU populations. However, the trajectories, determinants and prognoses of muscle strength changes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the trajectory and determinants of ICU\u2010AW in critical illness and its impact on 60\u2010day postadmission mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>A multicentre prospective cohort study was conducted, involving critically ill patients from 10 ICUs across five tertiary hospitals in Fujian Province, China. Patients were evaluated using the Medical Research Council (MRC) scale at three time points: within 48\u2009h of ICU admission or within 24\u2009h of regaining consciousness (T1), within 24\u2009h of ICU discharge (T2) and at the time of hospital discharge (T3). The latent class growth mixed model was utilized for data analysis, and multivariable logistic regression was employed to examine the determinants of muscle strength trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study encompassed 343 patients from five tertiary hospitals. Three latent trajectory groups were identified: a low\u2010level decline group (5.83%), a medium\u2010level stability group (25.36%) and a high\u2010level recovery group (68.81%). Multivariable logistic regression revealed that Charlson comorbidity index (CCI) and alcohol consumption significantly influenced the trajectory of muscle strength development in ICU patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The mortality rate at 60\u2009days was significantly higher in both the low\u2010level decline and medium\u2010level stability groups compared with the high\u2010level recovery groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identified three muscle strength trajectories in ICU patients: low\u2010level decline, medium\u2010level stability and high\u2010level recovery. CCI and alcohol consumption significantly influenced these trajectories. The lower 60\u2010day mortality rate in the high\u2010level recovery group underscores the need for early intervention and tailored care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Developing targeted rehabilitation strategies for those at risk of low\u2010level decline or medium\u2010level stability group is challenging and may potentially improve recovery and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13209","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T21:53:40Z","timestamp":1733349220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trajectory and determinants of intensive care unit\u2013acquired weakness in critical illness: A multicentre, prospective, longitudinal study"],"prefix":"10.1111","volume":"30","author":[{"given":"Xue\u2010Xian","family":"Chen","sequence":"first","affiliation":[{"name":"Critical Care Medicine Ningde Municipal Hospital of Ningde Normal University  Ningde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Nursing Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Ningde Municipal Hospital of Ningde Normal University  Ningde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Nanping City First Hospital  Nanping China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Ning","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Respiratory and Intensive Care Unit Putan College Affiliated Hospital  Putian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Lian","family":"Xu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Longyan City First Hospital  Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1141-6608","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nursing First Affiliated Hospital of Fujian Medical University  Fuzhou 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