{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:55:27Z","timestamp":1775976927186,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal timing for exchanging an endotracheal tube for a tracheostomy cannula in patients with hypoxic\u2010ischaemic encephalopathy is controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of early versus late tracheostomy on the prognosis of patients with hypoxic\u2010ischaemic encephalopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The study was an observational retrospective study that followed the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. We included adults with hypoxic\u2010ischaemic encephalopathy who underwent tracheostomy between January 2012 and September 2020. The patients were classified into early or late tracheostomy groups. To eliminate differences in baseline characteristics, propensity score matching was conducted, and the outcomes between the two groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 132 patients were included, and through propensity score matching, 54 pairs of patients were matched. The early tracheostomy group showed a significant reduction in the duration of mechanical ventilation (median, 12\u2009days; interquartile range 7\u201320 vs. median, 28\u2009days; interquartile range, 15.75\u201358.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), intensive care unit length of stay (median, 14.5\u2009days; interquartile range, 6.75\u201326 vs. median, 35\u2009days; interquartile range, 20\u201359,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and hospital length of stay (median, 19.5\u2009days; interquartile range, 10.87\u201336.5 vs. median, 39.5\u2009days; interquartile range, 22\u201366,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Over a 1\u2010year follow\u2010up period, there were no significant differences between the two groups regarding inhospital mortality (57.4% vs. 46.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.248), 30\u2010day mortality (59.3% vs. 46.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.177) and 1\u2010year mortality (61.1% vs. 48.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.176).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with hypoxic\u2010ischaemic encephalopathy undergoing mechanical ventilation, early tracheostomy is associated with a reduction in the duration of mechanical ventilation and decreased intensive care unit and hospital length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>For patients with hypoxic\u2010ischaemic encephalopathy who are at a high risk of requiring prolonged mechanical ventilation, the benefits of early tracheostomy suggest considering it a viable treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.13268","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T02:55:36Z","timestamp":1740624936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of early versus late tracheostomy with prognosis in hypoxic\u2010ischaemic encephalopathy patients: A propensity\u2010matched cohort 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Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University\/West China School of Nursing Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University\/West China School of Nursing Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijie","family":"Li","sequence":"additional","affiliation":[{"name":"West China School of Public Health, West China Second Hospital Sichuan University  Chengdu 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