{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:53:15Z","timestamp":1787928795233,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The extravasation of non\u2010cytotoxic drugs is a risk posed by intravenous therapy, particularly in critically ill patients who often require multiple intravenous medications. This risk must be promptly addressed to prevent morbidity, increased therapy costs and prolonged length of stay, especially in critical care units. Therefore, it is critical to define the specific measures that should be undertaken to approach each situation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this research was to describe the extravasation of non\u2010cytotoxic drugs occurring in a tertiary hospital and to assess the effectiveness and safety of the internal protocol applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This was a single\u2010centre, retrospective, observational study based on real world data from adult and paediatric patients experiencing extravasation of a non\u2010cytotoxic drug between June 2018 and June 2023. To perform the analysis, demographic, patient, intravenous therapy, extravasation and treatment variables were collected and computed using descriptive statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 61 patients. The median age was 63.0 (IQR 3.5\u201374.5) years, and participants were grouped into neonates, children and adults. Among the subjects studied, 80% had at least one risk factor that made them liable to experience an extravasation. Drug groups involved were radiological contrasts (42.6%), parenteral nutrition and electrolytes (29.5%), vasoactive and cardiovascular system drugs (14.8%), antibiotics (8.2%), other analgesics and antipyretics (1.6%), expectorants (1.6%) and alimentary tract and metabolism drugs (1.6%). Adequacy of the protocol was reported in 73.8% of the cases with complete recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The work reported here contributes to improving evidence about the management of extravasation episodes. Our findings suggest that patient\u2010centred team\u2010based protocolizing is a key strategy to achieve the effectiveness and safety of non\u2010cytotoxic drugs in real world practice. This protocol could allow other institutions to enhance safety related to intravenous therapy. Moreover, maintaining a surveillance strategy will enable the continuous collection of data on these adverse events, facilitating ongoing improvement and reinforcement of good practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Implementing a standardized protocol for managing non\u2010cytotoxic drug extravasation can significantly enhance patient safety and improve outcomes in both adult and paediatric populations in critical care settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70020","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T05:09:40Z","timestamp":1742447380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real world data on the management of non\u2010cytotoxic drug extravasation: An observational retrospective study in paediatric and adult patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3201-1230","authenticated-orcid":false,"given":"Marta","family":"Blazquez\u2010Vidal","sequence":"first","affiliation":[{"name":"Pharmacy Department Hospital Universitari General de Catalunya\u2010Quironsalud  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-363X","authenticated-orcid":false,"given":"Ines","family":"Garcia\u2010del Valle","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital Universitari General de Catalunya\u2010Quironsalud  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-2623","authenticated-orcid":false,"given":"Patricia","family":"Amoros\u2010Reboredo","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital de Sant Pau, Digital Impulse, Strategy and Transformation Area, Hospital de Sant Pau, Institut de Recerca Sant Pau (IR SANT PAU), PHAGEX: Pharmacotherapy, Genomics and Exposomics Research Group Blanquerna, Universitat Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-2180","authenticated-orcid":false,"given":"Miguel Angel","family":"Diaz\u2010Herrera","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital Universitari General de Catalunya\u2010Quironsalud  Barcelona Spain"},{"name":"Complex Wounds South Metropolitan Primary Care Institut Catal\u00e0 de la Salut  Barcelona Spain"},{"name":"Department of Fundamental and Clinical Nursing, Faculty of Nursing Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6923-276X","authenticated-orcid":false,"given":"Laura","family":"Val\u2010Prat","sequence":"additional","affiliation":[{"name":"Pharmacy 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