{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:21:32Z","timestamp":1793582492927,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intensive care unit\u2010acquired weakness (ICU\u2010AW) causes prolonged hospitalisations and higher mortality. Systematic reviews and meta\u2010analyses (SR\/MA) regarding ICU\u2010AW and early rehabilitation need a synthesis of the existing evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to summarise findings from several SR\/MA to provide an overview of early rehabilitation as a means to prevent ICU\u2010AW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This was an umbrella review of SR\/MA. Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis and Joanna Briggs Institute guidelines were used for the process. MEDLINE, Embase, Cochrane Database of Systematic Reviews and Airiti Library were searched for keywords. A search was conducted for papers published from the inception of the databases up to January 2025. Neither language nor publication year was restricted. A meta\u2010analyses would be conducted if there were inconsistencies in the current SR\/MA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An analysis of seven SRs with a quality above medium was conducted. Sixty\u2010nine primary studies from seven SRs discussed early rehabilitation in preventing ICU\u2010AW. According to meta\u2010analyses, early rehabilitation can significantly reduce the incidence of ICU\u2010AW, with a risk difference of \u22120.10 (95% CI: \u22120.18 to \u22120.03,\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20092.580,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Subgroup analysis further revealed that initiating rehabilitation within 1\u20133\u2009days of ICU admission was associated with a 13% lower risk of ICU\u2010AW (RD: \u22120.13; 95% CI: \u22120.22 to \u22120.04;\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20092.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Other subgroup analyses showed no statistically significant differences. The type of early rehabilitation that was most effective could not be determined due to the variability in interventions and outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early rehabilitation could significantly prevent ICU\u2010AW incidence. The meta\u2010analysis indicated that the early rehabilitation group has a 10% lower ICU\u2010AW incidence risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Providing early rehabilitation should be a nursing priority in the ICU in order to prevent ICU\u2010AW and enhance patient recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70113","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T08:34:26Z","timestamp":1753691666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preventing\n                    <scp>ICU<\/scp>\n                    \u2010Acquired Weakness With Early Rehabilitation: An Umbrella Review of Systematic Reviews and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Eri Yanuar Akhmad Budi","family":"Sunaryo","sequence":"first","affiliation":[{"name":"Department of Nursing, College of Medicine National Cheng Kung University  Tainan City Taiwan"},{"name":"School of Nursing, Faculty of Medicine State University of Malang  Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-4409","authenticated-orcid":false,"given":"Huan\u2010Fang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Medicine National Cheng Kung University  Tainan City Taiwan"},{"name":"Taiwan Holistic Care Evidence Implementation Center: A JBI Affiliation Center  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Sofia","sequence":"additional","affiliation":[{"name":"General Intensive Care Unit Dr Hasan Sadikin Public Hospital  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiching","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Medicine National Cheng Kung University  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Medicine National Cheng Kung University  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Tien","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Medicine National Cheng Kung University  Tainan City 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