{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:00:23Z","timestamp":1790352023341,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In individuals with sepsis, the most frequent neurological consequence is sepsis\u2010associated delirium (SAD). SAD can cause long\u2010term neuropsychiatric aftereffects such as anxiety disorders and cognitive impairment in addition to dramatically raising death rates in the intensive care unit (ICU) and during hospital stays. However, the correlation between nutritional status and SAD in patients with sepsis remains undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the correlation between malnutrition and the incidence of SAD in sepsis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      This research performed a retrospective analysis of adult patients with sepsis who were admitted to the ICU for the initial time. It investigated the association between malnutrition and delirium using logistic regression analysis. It employed propensity score matching, conducted stratified analysis and utilised\n                      <jats:italic>E<\/jats:italic>\n                      \u2010value for sensitivity analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 25\u2009716 patients, of whom 3132 were classified as malnourished and 22\u2009584 were non\u2010malnourished. The malnourished cohort demonstrated a twofold increased risk of delirium relative to the non\u2010malnourished cohort (26.56% vs. 12.90%). Multifactorial logistic regression demonstrated a significant positive correlation between malnutrition and the occurrence of delirium in sepsis patients within a fully adjusted model (odds ratio [OR]\u2009=\u20092.07, 95% confidence interval [CI]\u2009=\u20091.88\u20132.29). The findings remained consistent following a series of sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Malnutrition is strongly correlated with the occurrence of delirium in patients with sepsis. The significance of addressing malnutrition in sepsis patients within the ICU warrants attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>ICU nurses should prioritise the assessment of malnutrition, particularly among patients with sepsis. Timely identification and nutritional intervention in these patients may reduce care costs and lower the risk of delirium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70130","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:55:31Z","timestamp":1754988931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Malnutrition and Sepsis\u2010Associated Delirium: A Retrospective Analysis of the\n                    <scp>MIMIC<\/scp>\n                    \u2010\n                    <scp>IV<\/scp>\n                    Database"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0698-8074","authenticated-orcid":false,"given":"Weixi","family":"Tan","sequence":"first","affiliation":[{"name":"School of Nursing School of Public Health, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfang","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Nursing School of Public Health, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5711-7440","authenticated-orcid":false,"given":"Chengcheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Nursing School of Public Health, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing School of Public Health, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Dai","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xu","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danghong","family":"Sun","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56050240"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.940779"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2489-3"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2016.08.005"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56100527"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.183"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2415-8"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04143-5"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.01.003"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071069"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.037"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01899-x"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-023-1938-5"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.13136"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.06.044"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.21.2703"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2020.103782"},{"key":"e_1_2_17_21_1","article-title":"First Trimester Fetal Growth Restriction and Cardiovascular Risk Factors in School Age Children: Population Based Cohort Study","volume":"348","author":"Jaddoe V. 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