{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:13:59Z","timestamp":1790723639925,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early mobilisation (EM) is a rehabilitative approach hypothesised to improve functional and clinical outcomes in patients with traumatic brain injury (TBI). However, its benefits remain controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the influence of EM on neurological recovery, motor function, quality of life (QoL) and clinical outcomes in patients with TBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was performed. We systematically searched PubMed, Embase, Cochrane Library, Wanfang and CNKI databases for relevant randomised controlled trials (RCTs). Outcomes included changes in National Institutes of Health Stroke Scale (NIHSS), Fugl\u2013Meyer Assessment (FMA), Functional Independence Measure (FIM), QoL, mortality and adverse events. A random\u2010effects model was used to pool the results by incorporating heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven RCTs with 898 patients with TBI were included. EM significantly reduced NIHSS scores (MD: \u22124.51, 95% CI: \u22125.60 to \u22123.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) and improved FMA scores (MD: 5.39, 95% CI: 3.81\u20136.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200931%), indicating enhanced neurological recovery and motor function. QoL scores also improved with EM (SMD: 0.80, 95% CI: 0.48\u20132.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200942%). However, EM did not significantly influence FIM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15) or mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). Trends towards lower adverse event rates were observed but did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EM is associated with improved neurological and motor recovery and enhanced QoL in patients with TBI. While its impact on mortality and adverse events requires further validation, this evidence supports incorporating EM into standard TBI rehabilitation protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>The findings of this meta\u2010analysis highlight the importance of early mobilisation (EM) as a key component of rehabilitation for patients with traumatic brain injury. EM significantly improves neurological recovery, motor function and quality of life, supporting its integration into standard clinical practice. Given the potential for improved patient outcomes, healthcare providers, particularly nurses and rehabilitation specialists, should prioritise safe and individualised EM protocols to enhance functional recovery while minimising risks.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      The protocol of the meta\u2010analysis has been registered at PROSPERO with the identifier CRD42025640625\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70166","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:00:17Z","timestamp":1758088817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Early Mobilisation on the Clinical Outcomes of Patients With Traumatic Brain Injury"],"prefix":"10.1111","volume":"30","author":[{"given":"Fei","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7989-7328","authenticated-orcid":false,"given":"Yiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00309-X"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12222266"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1318-1"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2024.1326115"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brain.2024.100092"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093283"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.003"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3281394"},{"issue":"3","key":"e_1_2_17_11_1","article-title":"Early Intervention (Mobilization or Active Exercise) for Critically Ill Adults in the Intensive Care Unit","volume":"3","author":"Doiron K. 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