{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:05:54Z","timestamp":1784167554809,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Atat\u00fcrk \u00dcniversitesi","doi-asserted-by":"publisher","award":["BAP\u2010TCD\u20102021\u201010011"],"award-info":[{"award-number":["BAP\u2010TCD\u20102021\u201010011"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Prone positioning (PP) is widely used to improve oxygenation in acute respiratory distress syndrome (ARDS), but evidence in mechanically ventilated COVID\u201019 ARDS is heterogeneous.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To evaluate the effect of 16\u2010h daily PP on oxygenation, ventilation, laboratory and radiological parameters in intubated patients with COVID\u201019\u2013related ARDS.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n \n In this prospective cohort, 40 intubated patients were followed for 3\u2009days: PP group (\n n<\/jats:italic>\n \u2009=\u200920; PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n \u2009\u2264\u2009100) and supine position (SP) group (\n n<\/jats:italic>\n \u2009=\u200920; PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n \u2009\u2264\u2009200). Ventilator settings, oxygenation\/ventilation parameters (PaO\n 2<\/jats:sub>\n , PaCO\n 2<\/jats:sub>\n , HCO\n 3<\/jats:sub>\n , lactate, pH and SaO\n 2<\/jats:sub>\n ), PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n ratio, haematologic\/biochemical markers (C\u2010reactive protein (CRP), fibrinogen, D\u2010dimer, ferritin, lymphocyte count, procalcitonin, platelet count and LDH) and daily chest radiographs were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Within\u2010group analyses in the PP group showed significant changes over time in PaO\n 2<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.024), PaCO\n 2<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.035), PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n (\n p<\/jats:italic>\n < 0.001), pH (\n p<\/jats:italic>\n = 0.004), fibrinogen (\n F<\/jats:italic>\n = 7.600;\n p<\/jats:italic>\n = 0.002), procalcitonin (\n F<\/jats:italic>\n = 3.828;\n p<\/jats:italic>\n = 0.043), platelet count (\n F<\/jats:italic>\n = 6.486;\n p<\/jats:italic>\n = 0.013), and LDH (\n F<\/jats:italic>\n = 8.862;\n p<\/jats:italic>\n = 0.002) no significant within group changes were observed in the SP group (fibrinogen,\n p<\/jats:italic>\n = 0.068; procalcitonin\n p<\/jats:italic>\n = 0.093; platelet\n p<\/jats:italic>\n = 0.068; LDH\n p<\/jats:italic>\n = 0.227). SaO\n 2<\/jats:sub>\n was higher in the PP group than in the SP group at M3 on Day 2: PP: 92.13 \u00b1 5.5 vs. SP: 88.24 \u00b1 6.02%;\n t<\/jats:italic>\n = 2.131; mean difference +3.89 (95% CI 0.19 to 7.57;\n p<\/jats:italic>\n = 0.040). CRP decreased over time in both groups (PP:\n p<\/jats:italic>\n = 0.008; SP:\n p<\/jats:italic>\n = 0.001). Radiographically, ground\u2010glass opacities decreased in 70% of PP vs. 25% of SP patients (\n p<\/jats:italic>\n \u2009=\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study suggests that the prone position may be more effective in improving clinical and oxygenation parameters in intubated COVID\u201019 patients with severe ARDS.<\/jats:p>\n <\/jats:sec>\n \n Relevance to Clinical Practice<\/jats:title>\n This study provides evidence to guide the management of COVID\u201019\u2013related ARDS. The findings may support ICU nurses' clinical decisions and improve care protocols for similar patients. Clinically, maintaining ARDS patients in the prone position (PP) aids recovery. In intensive care units, experienced nurses should ensure correct patient positioning and provide continuous monitoring.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nicc.70266","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:14:35Z","timestamp":1767845675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Prone Position on Oxygenation Parameters of Intubated Patients Due to\n COVID<\/scp>\n \u201019\u2010Related\n ARDS<\/scp>\n : Prospective Observational Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8796-6497","authenticated-orcid":false,"given":"Reva","family":"Balci Akpinar","sequence":"first","affiliation":[{"name":"Ataturk University Faculty of Nursing, Department of Nursing Fundamentals Erzurum 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