{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:23:25Z","timestamp":1785338605906,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late\u2010onset sepsis is a major cause of morbidity and mortality in NICUs. This study reports the attributable mortality of late\u2010onset sepsis across different gestational age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The objective of this study is to assess the attributable mortality of neonatal late\u2010onset sepsis according to gestational age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A matched cohort study using a 10\u2010year, single\u2010centre historical cohort with propensity score matching to reduce confounders. Attributable mortality was determined in the total matched cohort and by gestational age: extremely preterm (&lt;\u200928\u2009weeks), very preterm (28\u201332\u2009weeks + 6\u2009days), late preterm (33\u201336\u2009weeks +6\u2009days) and full\u2010term (\u2265\u200937\u2009weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The matched cohort included 4210 neonates. Attributable mortality of late\u2010onset sepsis in the total cohort was 6.1% (95% CI, 4.7\u20137.8). It was highest in neonates born between 28 and 36\u2009weeks: 7.1% (95% CI, 4.5\u20139.8) for very preterm, 8.1% (95% CI, 5.1\u201311.1) for late preterm and 2.8% (95% CI, 0.01\u20135.8) for term neonates. For extremely preterm newborns, it was 6.6% (95% CI, \u22121.1 to 14.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late\u2010onset sepsis significantly impacts neonates, particularly those born between 28 and 36\u2009weeks, even after adjusting for confounders. Larger\u2010scale studies are needed to further understand the impact across gestational ages. Integrating gestational age into risk stratification tools may improve prevention, early detection and management of neonatal late\u2010onset sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Gestational age\u2013specific risk profiles enable targeted monitoring and timely intervention for neonates at greatest risk of sepsis. Personalised care strengthens prevention and management, while nursing expertise in this context is vital for early detection and reducing mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70316","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:26:03Z","timestamp":1769768763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Attributable Mortality of Late\u2010Onset Sepsis in the Neonatal\n                    <scp>ICU<\/scp>\n                    According to Gestational Age: A Historical Propensity Score Matched Cohort Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-0852","authenticated-orcid":false,"given":"Elsa","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"},{"name":"Institute of Nursing Excellence, Royal College of Nursing  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Smets","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Deschepper","sequence":"additional","affiliation":[{"name":"Data Science Institute Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Verstraete","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-0345","authenticated-orcid":false,"given":"Stijn","family":"Blot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"},{"name":"UQ Centre for Clinical Research The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_16_2_1","volume-title":"Global Report on the Epidemiology and Burden of Sepsis: Current Evidence, Identifying Gaps and Future Directions","author":"World Health Organization","year":"2020"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(18)30063\u20108"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7976"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.089"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.178798"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2019.1568871"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010021\u201001749\u20103"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2019.03.003"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010016\u20102726\u20106"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2024.103927"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723654"},{"issue":"3","key":"e_1_2_16_14_1","first-page":"145","article-title":"A Preliminary Study on Neonatal Septicaemia in a Tertiary Referral Hospital Paediatric Unit","volume":"44","author":"Perera J.","year":"1999","journal-title":"Ceylon Medical Journal"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004179"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102017\u2010000347"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23580"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2023.103421"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/675836"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60820\u20104"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.08.015"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj149"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3263"},{"key":"e_1_2_16_24_1","volume-title":"Modern Epidemiology","author":"Rothman K. 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