{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:24:07Z","timestamp":1777865047200,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Liver failure can lead to severe disorders in the body's metabolism, detoxification, synthesis and other functions, with a high mortality rate of 60%\u201390%. The dual plasma molecular adsorption system (DPMAS) is a new artificial liver technology that has received much attention in recent years. However, it cannot provide coagulation factors, albumin or other substances during the treatment process and may even consume albumin during the adsorption process. The DPMAS typically needs to be used in combination with plasma exchange (PE). Few studies have compared PE alone and DPMAS + PE.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n This study aimed to explore the clinical efficacy and nursing methods of different artificial liver treatments for patients with acute drug\u2010induced liver injury.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n The clinical data of patients with liver failure admitted to the intensive care unit of our hospital were retrospectively analysed to identify a PE group and a sequential PE group, comprising DPMAS with PE (DPMAS + PE). The changes in liver function and coagulation function index before and after treatment and the occurrence of adverse reactions were compared.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total,\n n<\/jats:italic>\n \u2009=\u200957 patients (PE\n n<\/jats:italic>\n \u2009=\u200914, DPMAS + PE\n n<\/jats:italic>\n \u2009=\u200943) participated in the study. There was no significant difference in alanine aminotransferase (ALT), aspartate aminotransferase (AST) or total bilirubin (TBIL) levels before treatment (\n p<\/jats:italic>\n \u2009>\u20090.05). After treatment, ALT levels were higher in the PE group than in the DPMAS + PE group (317.72\u2009\u00b1\u2009604.24 vs. 276.02\u2009\u00b1\u2009763.04, respectively), whereas TBIL levels were lower in the former than in the latter (237.91\u2009\u00b1\u2009124.34 vs. 297.95\u2009\u00b1\u2009153.38). The international normalised ratio (INR) was higher in the DPMAS + PE group than in the PE group (1.84\u2009\u00b1\u20090.66 vs. 1.66\u2009\u00b1\u20090.72) and prothrombin activity (30.51\u2009\u00b1\u20097.91 vs. 34.62\u2009\u00b1\u20098.43) was lower, indicating that DPMAS + PE had a better effect on ALT and AST levels, but PE alone was more effective in improving TBIL and INR levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The two artificial liver treatments can improve markers of liver function in patients with liver failure and help with liver function recovery.<\/jats:p>\n <\/jats:sec>\n \n Relevance to Clinical Practice<\/jats:title>\n Both artificial liver therapies effectively support patients awaiting transplantation. Successful management, particularly of the combined DPMAS + PE modality, demands specialised nursing expertise. Nurses must vigilantly monitor circuit pressure and coagulation parameters and adjust anticoagulant doses proactively to ensure treatment safety and efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nicc.70326","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:28:14Z","timestamp":1770528494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Two Artificial Liver Treatments for Acute Liver Failure: A Retrospective Observational Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Xiulian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunology, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4048-3895","authenticated-orcid":false,"given":"Yanmei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing You'an Hospital Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021844"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1750"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010137\u201012\u2010200212170\u201000007"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002340"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010019\u201009946\u20103"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0103"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.002"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12501019"},{"issue":"4","key":"e_1_2_15_11_1","first-page":"270","article-title":"Comparative Analysis of Three Artificial Liver Models in the Treatment of Patients With Acute\u2010On\u2010Chronic Liver Failure","volume":"8","author":"Wang X.","year":"2020","journal-title":"Practical Journal of Organ Transplantation (Electronic Version)"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28650"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872\u2010034X.2011.00860.x"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21690"},{"issue":"35","key":"e_1_2_15_15_1","first-page":"6","article-title":"The Change of Intraoperative Blood Coagulation Function in Patients With Liver Transplantation and Influencing Factors","volume":"15","author":"Ma H.","year":"2007","journal-title":"Journal of World Chinese Digest 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Information"},{"issue":"1","key":"e_1_2_15_23_1","first-page":"85","article-title":"Effect of Plasma Exchange and Sequential Double Plasma Molecular Adsorbent Therapy on Short Survival in Patients With Hepatitis B Virus\u2010Induced Acute on Chronic Liver Failure","volume":"22","author":"Zhang J.","year":"2019","journal-title":"Journal of Practical Hepatology"},{"issue":"9","key":"e_1_2_15_24_1","first-page":"2078","article-title":"Influencing Factors for Hypotension in Patients Undergoing Double Plasma Molecular Adsorption System Artificial Liver Support Therapy","volume":"38","author":"Hu D.","year":"2022","journal-title":"Journal of Clinical Hepatology"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr601"},{"issue":"5","key":"e_1_2_15_26_1","first-page":"4928","article-title":"Effect of High\u2010Quality Nursing Intervention on Psychological Emotion, Life Quality and Nursing Satisfaction of Patients With Nasopharyngeal Carcinoma Undergoing Radiotherapy","volume":"13","author":"Li C.","year":"2021","journal-title":"American Journal of Translational Research"}],"container-title":["Nursing in Critical 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