{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:26:02Z","timestamp":1777865162724,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis is life\u2010threatening due to organ dysfunction from a dysregulated host response. Despite macrohemodynamic stabilisation, microcirculatory disturbances may persist. Capillary refill time (CRT) is a simple bedside indicator of microcirculatory perfusion, but its dynamic prognostic value over time is underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To observe CRT changes in sepsis patients and evaluate its predictive value at different time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled sepsis patients receiving bundle therapy at a single centre. Patients were grouped by 28\u2010day survival. Baseline data, CRT, lactate (Lac) and central venous pressure (CVP) were measured at eight time points (pre\u2010treatment to 72\u2009h) compare inter\u2010group and intra\u2010group differences. Spearman's correlation assessed CRT\u2010Lac\/CVP relationships. ROC analysis evaluated CRT's prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 86 patients (70 survived, 16 non\u2010survivors), significant inter\u2010group differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were found in age, SOFA score, lactate and vasoactive drug dosage. CRT and Lac differed significantly between groups at all time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while CVP differed at 3, 24 and 72\u2009h. Intra\u2010group comparisons showed significant changes in all parameters over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). CRT correlated negatively with CVP in survivors (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.358,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In non\u2010survivors, CRT positively correlated with Lac and negatively with CVP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.416 and \u22120.553, both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). ROC analysis indicated 3\u2010h post\u2010treatment CRT had the highest predictive value (AUC\u2009=\u20090.981, sensitivity 93.8%, specificity 97.1%). Spearman correlation analysis revealed a positive correlation between \u0394CRT\u2083h and \u0394Lac\u2083h in both patient groups: \u03c1\u2009=\u20090.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035 in the survival group and \u03c1\u2009=\u20090.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 in the non\u2010survival group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRT is a valuable prognostic marker in sepsis, with 3\u2010h CRT showing the strongest predictive performance. Its monitoring may guide early treatment decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>This study validates nurse\u2010measured capillary refill time (CRT) as a simple, early\u2010warning tool. A prolonged 3\u2010h CRT accurately identifies high\u2010risk septic patients, enabling nurses to prioritise care and guide timely resuscitation at the bedside.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70347","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:03:02Z","timestamp":1770008582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Prognostic Value of Capillary Refill Time in Patients With Sepsis: A Prospective Cohort Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7641-6612","authenticated-orcid":false,"given":"Lina","family":"Ma","sequence":"first","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1271-4930","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"},{"name":"Health Care Research Center for Xinjiang Regional Population  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"issue":"10","key":"e_1_2_15_2_1","first-page":"901","article-title":"Surviving Sepsis Campaign Guideline Update:Problems and Progress","volume":"47","author":"Pan P.","year":"2024","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07543-8"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2025.01.054"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13836"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0511-1"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38035"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc14726"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503775"},{"issue":"2","key":"e_1_2_15_10_1","first-page":"160","article-title":"Research Progress of Microcirculatory Disorders Associated With Sepsis","volume":"6","author":"Shen Y.","year":"2020","journal-title":"Chinese Journal of Critical Care & Intensive Care Medicine (Electronic Edition)"},{"issue":"7","key":"e_1_2_15_11_1","article-title":"Surviving Sepsis Campaign Guidelines 2021: Highlights for the Practicing Clinician","volume":"132","author":"Oczkowski S.","year":"2022","journal-title":"Polskie Archiwum Medycyny Wewn\u0119trznej"},{"issue":"12","key":"e_1_2_15_12_1","first-page":"785","article-title":"Predictive Value of the Change Rate of Capillary Refill Time Before and After Fluid Resuscitation on the Risk of Organ Function Deterioration in Patients With Sepsis\u2010Associated Hyperlactatetatemia","volume":"22","author":"Li J.","year":"2021","journal-title":"Journal of Clinical Emergency"},{"key":"e_1_2_15_13_1","volume-title":"Predictive Value of Early Sublingual Microcirculation Combined With CRT Monitoring for Condition Assessment and Prognosis of Patients With Septic Shock","author":"Li Q.","year":"2021"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003119"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07361-3"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05285-y"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-04524-5"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-03143-5_7"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000001038"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20220004-en"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000000705"},{"issue":"4","key":"e_1_2_15_24_1","first-page":"199","article-title":"Application of Capillary Refill Time in Septic Shock","volume":"6","author":"You J.","year":"2022","journal-title":"Journal of Practical Shock (In Chinese and English)"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.05.044"},{"key":"e_1_2_15_26_1","volume-title":"Study on the impact and clinical significance of Different Types of Fluid Resuscitation on the Glycocalyx in Patients with Early Sepsis and septic Shock","author":"Dong L.","year":"2024"},{"issue":"9","key":"e_1_2_15_27_1","first-page":"891","article-title":"Predictive Value of APACHE II Score Combined With CVP for in\u2010Hospital Death in Patients With Septic Shock","volume":"50","author":"Pan K.","year":"2024","journal-title":"Jiangsu Medicine"},{"issue":"9","key":"e_1_2_15_28_1","first-page":"6","article-title":"Comparison of Clinical Effects of Fluid Resuscitation Under PiCCO and CVP Monitoring in the Treatment of Septic Shock Combined With Severe Acute Respiratory Distress Syndrome","volume":"21","author":"Cai X.","year":"2024","journal-title":"Medical Innovation of China"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102123"}],"container-title":["Nursing in Critical 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