{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:26:55Z","timestamp":1777865215639,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium is a significant concern for mechanically ventilated patients in intensive care units. Non\u2010pharmacological strategies may help prevent delirium, but without a standard protocol, interventions are inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study assessed existing evidence on non\u2010pharmacological interventions for decreasing delirium in mechanically ventilated ICU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We applied evidence summary reporting standards and the \u20186S\u2019 pyramid model, searching key databases and webpages with a top\u2010down focus on high\u2010level evidence about non\u2010pharmacological delirium prevention. The search covered literature published up until March 13, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen documents were included: two guidelines, three expert consensuses, seven systematic reviews, three randomised controlled trials and three clinical decision analyses. The integrated evidence was grouped into six domains: assessment and diagnosis, positive internal experience, environment control, physical function recovery, traditional Chinese medicine (including five\u2010animal play, five\u2010element music therapy and acupuncture) and bundled interventions. This resulted in the development of 26 evidence\u2010based recommendations\u201420 Grade A (strong recommendation) and six Grade B (weak recommendation), indicating a high degree of consensus and clinical feasibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We synthesised 26 of the highest\u2010quality studies from six domains to generate a comprehensive framework for non\u2010pharmacological delirium prevention in mechanically ventilated ICU patients. These evidence\u2010based suggestions provide practical clinical advice that healthcare professionals can adapt based on local resources and clinical contexts to guarantee safety and efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>This study reviewed the best evidence for the non\u2010pharmacological prevention of delirium in mechanically ventilated ICU patients, from which it derived a comprehensive framework for clinical practice. This framework can reduce the frequency and length of delirium episodes, improve patient health outcomes and improve overall nursing quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>This review was submitted by Fudan University's Evidence\u2010Based Nursing Center with registration number ES20246510.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70354","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T02:33:38Z","timestamp":1770258818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Summarising the Best Evidence for Non\u2010Pharmacological Prevention of Delirium in Mechanically Ventilated\n                    <scp>ICU<\/scp>\n                    Patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4211-4821","authenticated-orcid":false,"given":"Jiaxin","family":"Li","sequence":"first","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4856-5783","authenticated-orcid":false,"given":"Mengjuan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Henan Provincial People's Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng 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 Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengke","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Henan University  Kaifeng 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