{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:27:52Z","timestamp":1787682472334,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central venous catheters are essential in paediatric intensive care but are associated with catheter\u2010related bloodstream infections (CRBSIs) and skin complications. Chlorhexidine gluconate (CHG)\u2010impregnated dressings may reduce infection risk; however, concerns remain regarding their dermatological safety in vulnerable paediatric populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the dermatological safety of CHG\u2010impregnated dressings in critically ill paediatric patients requiring central venous catheters and to explore their impact on catheter\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A single\u2010blind, prospective randomised clinical trial was conducted in a tertiary paediatric intensive care unit. Within routine clinical practice, patients were randomly assigned to receive either a conventional transparent dressing or a dressing incorporating a 2% CHG gel pad. The primary outcome was the occurrence of tegumentary alterations at the catheter insertion site. Secondary outcomes included CRBSI incidence and catheter maintenance variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Skin alterations were identified in 14.0% of patients, with no significant differences between groups (16.8% vs. 11.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.202). However, dermatological alterations occurred at a significantly younger age in the CHG group (6.5\u2009\u00b1\u20094.8 vs. 46.0\u2009\u00b1\u200943.2\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), with a similar pattern for pruritus. Multivariable analysis showed a significant interaction between dressing type and age, indicating age\u2010dependent dermatological responses. CHG dressings were associated with fewer dressing changes and longer intervals between replacements. CRBSI incidence was lower in the CHG group (2.4% vs. 18.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), although this was a secondary outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CHG\u2010impregnated dressings showed an acceptable dermatological safety profile. Their use was associated with improved catheter\u2010related outcomes, although skin reactions occurred at younger ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>CHG dressings may support safer catheter management but require careful dermatological monitoring in infants. These findings may help inform dressing selection and catheter care strategies in paediatric intensive care settings where infection prevention and skin integrity must be balanced.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70554","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:06:35Z","timestamp":1782468395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dermatological Safety of Chlorhexidine\u2010Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-9958","authenticated-orcid":false,"given":"Francisco Javier","family":"Portero\u2010Prados","sequence":"first","affiliation":[{"name":"Red Cross Nursing School University of Seville  Seville Spain"},{"name":"Paediatric Intensive Care Unit Virgen del Roc\u00edo Hospital  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pab\u00f3n\u2010Carrasco","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Nursing, Physiotherapy and Podiatry University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Ponce\u2010Bland\u00f3n","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Nursing, Physiotherapy and Podiatry University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061115"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(15)00409\u20100"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.16\u20104\u2010e211"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.03.006"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1891\/0730\u20100832.37.2.105"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2004.10.007"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010014\u20100689\u2010y"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_2_18_10_1","volume-title":"Annual Epidemiological Report for 2017: Healthcare\u2010Associated Infections 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for Disease Control and Prevention (CDC) \u201cIntravascular Catheter\u2010Related Infection (BSI) Prevention Guidelines \u201dAtlanta: CDC accessed August 7 2025 https:\/\/www.cdc.gov\/infection\u2010control\/hcp\/intravascular\u2010catheter\u2010related\u2010infection\/index.html."},{"key":"e_1_2_18_27_1","unstructured":"Centers for Disease Control and Prevention (CDC) \u201cIntravascular Catheter\u2010Related Infection (BSI) Prevention Guidelines \u201dAtlanta: CDC accessed February 21 2025 https:\/\/www.cdc.gov\/infection\u2010control\/hcp\/intravascular\u2010catheter\u2010related\u2010infection\/index.html."},{"key":"e_1_2_18_28_1","unstructured":"Centers for Disease Control and Prevention (CDC) \u201cGuidelines for the Prevention of Intravascular Catheter\u2010Related Infections \u201dAtlanta: CDC (2011) accessed February 21 2025 https:\/\/www.cdc.gov\/infectioncontrol\/guidelines\/bsi\/."},{"key":"e_1_2_18_29_1","unstructured":"U.S. Food and Drug Administration (FDA) 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