{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:01:16Z","timestamp":1790773276750,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing in Critical Care"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survivors of critical illness are at high risk for developing chronic pain. However, evidence regarding new\u2010onset chronic pain in this specific population remains limited in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the incidence of chronic pain among Chinese intensive care unit (ICU) survivors at 3\u2009months after discharge and to identify associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This was a prospective study. The participants were adult ICU survivors from a mixed ICU of a tertiary hospital in Zhejiang, China. The Brief Pain Inventory (BPI) was used to assess pain at 3\u2009months after ICU discharge. Multivariable binary logistic regression was performed to identify factors independently associated with chronic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 328 ICU survivors, 109 (33.2%) reported new\u2010onset chronic pain, including 64 of 109 (58.7%) with mild pain (BPI average pain score 1\u20133), 42 of 109 (38.5%) with moderate pain (BPI average pain score 4\u20136) and 3 of 109 (2.8%) with severe pain (BPI average pain score 7\u201310). The shoulder was the most frequently reported pain site (46 of 109, 42.2%), and normal work was the daily domain most affected by pain. Multivariable analysis showed that pre\u2010existing chronic pain (OR\u2009=\u20094.77, 95% CI: 2.02\u201311.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), days with mechanical ventilation (OR\u2009=\u20091.27, 95% CI: 1.17\u20131.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and days with hyperinflammation (OR\u2009=\u20091.34, 95% CI: 1.18\u20131.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independently associated with the development of new\u2010onset chronic pain. Among 286 patients without pre\u2010existing chronic pain, 79 (27.6%) developed new\u2010onset chronic pain; mechanical ventilation duration and hyperinflammation remained independently associated with this outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately one\u2010third of ICU survivors experience chronic pain, with 41.3% reporting moderate\u2010to\u2010severe pain that interfered with daily functioning. These findings highlight the importance of systematic pain assessment and targeted follow\u2010up after ICU discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to Clinical Practice<\/jats:title>\n                    <jats:p>Post\u2010ICU follow\u2010up should include systematic assessment of chronic pain and pain\u2010related functional impairment alongside other PICS domains, including psychological distress, cognitive dysfunction and physical impairments, to ensure holistic, patient\u2010centred recovery after critical illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nicc.70715","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:01:53Z","timestamp":1790769713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Associated Factors for Chronic Pain After\n                    <scp>ICU<\/scp>\n                    Discharge: A Prospective Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-1799","authenticated-orcid":false,"given":"Jinyu","family":"Yin","sequence":"first","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4887-2334","authenticated-orcid":false,"given":"Tianhao","family":"Yu","sequence":"additional","affiliation":[{"name":"Nursing Department Zhejiang Provincial People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Shen","sequence":"additional","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5170-5002","authenticated-orcid":false,"given":"Xiangping","family":"Chen","sequence":"additional","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Qian","sequence":"additional","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-1705","authenticated-orcid":false,"given":"Yuewen","family":"Lao","sequence":"additional","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gong","sequence":"additional","affiliation":[{"name":"Nursing Department, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s13054-025-05521-5","article-title":"The Impact of Intensive Care Strain on Patients' Outcomes: A Multinational Observational Cohort (UNITE\u2010COVID) Study","volume":"29","author":"Kohler K.","year":"2025","journal-title":"Critical Care"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/cc12745","article-title":"An Exploration of Social and Economic Outcome and Associated Health\u2010Related Quality of Life After Critical Illness in General Intensive Care Unit Survivors: A 12\u2010Month Follow\u2010Up Study","volume":"17","author":"Griffiths J.","year":"2013","journal-title":"Critical Care"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2023.154359","article-title":"The Relationship Between Pain, Anxiety and Depression in Patients With Post\u2010Intensive Care Syndrome","volume":"78","author":"Docherty C.","year":"2023","journal-title":"Journal of Critical Care"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pmn.2017.11.005","article-title":"Prevalence, Location, and Characteristics of Chronic Pain in Intensive Care Survivors","volume":"19","author":"Langerud A. 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