{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:04Z","timestamp":1790744524982,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T00:00:00Z","timestamp":1351641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Improvement of gastroparesis (GP) symptoms has been documented in patients treated with gastric electrical stimulation (GES), but acceleration of gastric emptying (GET) is unpredictable. The aim of our study was to evaluate the advantage of adding surgical pyloroplasty (PP) to GES for improvement of GET and control of symptoms in diabetes mellitus (DM), idiopathic (ID), and postvagotomy (P\u2010V) GP.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 49 (17 \u2013 DM, 9 \u2013 ID, 23 \u2013 P\u2010V) consecutive GP patients: 38\u2003female; mean age 42 (21\u201373\u2003years); mean weight 158\u2003lbs (102\u2013245), underwent GES implantation, and 26 (53%) additionally received PP. Total Symptoms Score, 4\u2010h GET, adverse events (AEs), and days of hospitalizations were captured at baseline and at the last visit.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> The mean follow\u2010up was 7\u2003months. Total Symptoms Score in patients who received Enterra and PP or GES alone significantly improved compared to their baseline scores (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). GET improved by 64% at 4\u2003h (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) in patients with Enterra and PP, compared to 7% observed after GES therapy alone (ns). The most impressive acceleration of GET was seen in the P\u2010V group, who received both therapies (<jats:italic>P<\/jats:italic>\u2003=\u20030.004) and 8 (60%) of them normalized GET. No AEs accompanied the addition of PP to the Enterra surgery.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> (i) In drug\u2010refractory GP the addition of PP to GES substantially accelerated GET; (ii) The GET response in P\u2010V group was the most impressive; (iii) Significant symptom reductions were achieved by both procedures; and (iv) PP added to GES may sustain better long\u2010term symptoms control particularly in the P\u2010V setting.<\/jats:p>","DOI":"10.1111\/nmo.12032","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T02:31:15Z","timestamp":1351737075000},"page":"134","source":"Crossref","is-referenced-by-count":69,"title":["The addition of pyloroplasty as a new surgical approach to enhance effectiveness of gastric electrical stimulation therapy in patients with gastroparesis"],"prefix":"10.1111","volume":"25","author":[{"given":"I.","family":"Sarosiek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sarosiek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026665728213"},{"key":"e_1_2_10_3_2","first-page":"2589","article-title":"American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis","volume":"127","author":"Parkman HP","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2007.07.004"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.503"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01612.x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.055"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01008.x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2001\/628102"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000185690"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00023.2008"},{"issue":"1","key":"e_1_2_10_12_2","first-page":"16","article-title":"Gastroparesis \u2013 current concepts and considerations","volume":"10","author":"Hasler WL","year":"2008","journal-title":"Medscape J Med"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.1989"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90262-3"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1984.tb01206.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(79)80003-7"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.3.419"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26264"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1909-8"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2004.10.001"},{"key":"e_1_2_10_21_2","first-page":"1501","article-title":"Viral gastroparesis: a subgroup of idiopathic gastroparesis, clinical characteristics and long\u2010term outcome","volume":"92","author":"Bityutskiy L","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00605-6"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(85)80140-2"},{"key":"e_1_2_10_24_2","first-page":"39","article-title":"Postoperative gastrointestinal complaints after laparoscopic Nissen fundoplication","volume":"10","author":"Frantzides CT","year":"2006","journal-title":"JSLS"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70008-7"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1964.01310230141027"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-004-0035-z"},{"key":"e_1_2_10_28_2","first-page":"121","article-title":"Gastroparesis","volume":"4","author":"McCallum RW","year":"2001","journal-title":"Clin Perspect Gastroenterol"},{"key":"e_1_2_10_29_2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/archinte.1993.00410120051007","article-title":"The prevelance of metoclopramide\u2010induced tardive dyskinesia and acute extrpyramidal movement disorders","volume":"153","author":"Ganzini L","year":"1993","journal-title":"Arch Intern Med"},{"key":"e_1_2_10_30_2","first-page":"1251","article-title":"Randomized, placebo controlled trial of botulinum toxin A for the treatment of delayed gastric emptying","volume":"26","author":"Friedenberg FK","year":"2007","journal-title":"Gastroenterology"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068359"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00878-3"},{"issue":"5","key":"e_1_2_10_33_2","article-title":"Gastroparesis and gastric electrical stimulation: a useful option for gastroparesis","volume":"2","author":"McCallum RW","year":"2006","journal-title":"AGA Perspect"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04082.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.12.013"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00878-3"},{"issue":"9","key":"e_1_2_10_37_2","first-page":"28","article-title":"Gastric electrical stimulation: Who are the best Candidates and What are the results","author":"Namin F","year":"2005","journal-title":"Practical Gastroenterol"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00802-9"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1071"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00503.x"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70528-1"},{"key":"e_1_2_10_42_2","first-page":"M1151","article-title":"Is pyloroplasty a surgical option in the treatment of refractory gastroparesis?","volume":"132","author":"Nguyen LB","year":"2007","journal-title":"Gastroenterology"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)85574-1"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00605-6"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00760.x"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902722505"},{"key":"e_1_2_10_47_2","unstructured":"US Food and Drug Administration.H990014\u2013EnterraTM therapy system (formerly named gastric electrical stimulation (GES) system). Available at:http:\/\/www.fda.gov\/cdrh\/ode\/H990014sum.html. Accessed March 31 2000."},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.020"},{"key":"e_1_2_10_49_2","doi-asserted-by":"crossref","unstructured":"SarosiekI ForsterJ LinZ SarosiekJ RoeserK McCallumR.The addition of pyloroplasty is a new surgical approach that enhances the clinical outcome to gastric electrical stimulation (Enterra) in patients with post\u2010vagotomy gastroparesis compared to diabetic\/idiopathic gastroparesis. Abstract AGA 2008.Gastroenterology2008;134(Suppl):A\u2013550(abstract).","DOI":"10.1016\/S0016-5085(08)62567-6"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1607-6"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318182ee33"},{"key":"e_1_2_10_52_2","doi-asserted-by":"crossref","unstructured":"WaliaR BremmerRM HuangJL VarschKE SmithMA.Gastroparesis is common following Lung transplantation and may be ameliorated by Botox injection of the pylorus.Ann Mtg Int Soc Heart Lung Transplant2011 Meeting proceedings p. 129 abstract.","DOI":"10.1016\/j.healun.2011.01.346"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01389.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T01:22:55Z","timestamp":1698628975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,31]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/nmo.12032"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12032","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,31]]}}}