{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:56:12Z","timestamp":1790272572027,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Visceral hypersensitivity is one of the proposed underlying mechanisms in functional dyspepsia (FD). It is not clear whether visceral hypersensitivity in FD is a manifestation of a central sensitization also encompassing somatic sensitization. Transient receptor potential vanilloid\u20101 (TRPV\n                    <jats:sub>1<\/jats:sub>\n                    ) pathways are involved in gastric mechanosensory physiology and the TRPV\n                    <jats:sub>1<\/jats:sub>\n                    receptor agonist, capsaicin, has been used as a chemical stimulant.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    In this double\u2010blind, randomized study we evaluated both visceral and somatic sensory function in 34 FD patients and 42 healthy controls using quantitative sensory testing. Visceral pain sensitivity was assessed using a validated gastric pain model with oral capsaicin capsule titration and somatic pain sensitivity was determined by foot heat and hand electric stimulation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Key Results\u2002<\/jats:bold>\n                    The median capsaicin dose required to attain moderate pain was 0.5mg in FD and 1mg in controls (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.03). At these doses, mean pain intensities on a 0\u2013100 visual analog scale were greater for FD than controls [56.9 (95% confidence intervals, 52.2\u201361.5)\n                    <jats:italic>vs<\/jats:italic>\n                    45.1 (41.6\u201348.6), resp.] (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.005). Overall, mean somatic sensory and pain thresholds were similar in FD and control groups, but in a subgroup of FD pain hypersensitivity was seen on the hand and on the foot at different stimulation thresholds.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold>\n                    A majority of patients with FD have visceral chemo\u2010hypersensitivity involving TRPV\n                    <jats:sub>1<\/jats:sub>\n                    pathways. A substantial subgroup also has somatic hypersensitivity as evidence of central sensitization.\n                  <\/jats:p>","DOI":"10.1111\/nmo.12044","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T13:45:49Z","timestamp":1353505549000},"page":"246","source":"Crossref","is-referenced-by-count":41,"title":["Visceral and somatic sensory function in functional dyspepsia"],"prefix":"10.1111","volume":"25","author":[{"given":"X.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K. M","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Y","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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