{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:23:28Z","timestamp":1787495008835,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n There is little information regarding gender\u2010specific measurements of colonic transit and anorectal function in patients with defecation disorders (\n DD<\/jats:styled-content>\n ). To compare overall colonic transit by gender in\n DD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In 407 patients with constipation due to\n DD<\/jats:styled-content>\n diagnosed by a single gastroenterologist (1994\u20132012),\n DD<\/jats:styled-content>\n was characterized by anorectal manometry, balloon expulsion test, and colonic transit by scintigraphy. The primary endpoint was overall colonic transit (geometric center,\n GC<\/jats:styled-content>\n ) at 24\u00a0h (\n GC<\/jats:styled-content>\n 24). Effects of gender in\n DD<\/jats:styled-content>\n on colonic transit, and comparison with transit in 208 healthy controls were assessed by Mann\u2013Whitney rank sum test. Secondary endpoints were maximum anal resting (\n ARP<\/jats:styled-content>\n ) and squeeze (\n ASP<\/jats:styled-content>\n ) pressures. We also tested association of the physiological endpoints among\n DD<\/jats:styled-content>\n females by pregnancy history and among\n DD<\/jats:styled-content>\n patients by colectomy history.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n The\n DD<\/jats:styled-content>\n patients were 67 males (M) and 340 females (F). Significant differences by gender in\n DD<\/jats:styled-content>\n patients were observed in\n GC<\/jats:styled-content>\n 24 (median: M: 2.2; F: 1.8; P\u00a0=\u00a00.01),\n ARP<\/jats:styled-content>\n (median: M: 87.8\u00a0mmHg; F:\u00a082.4\u00a0mmHg; P\u00a0=\u00a00.04), and\n ASP<\/jats:styled-content>\n (median: M: 182.4\u00a0mmHg; F: 128.7\u00a0mmHg; P\u00a0<\u00a00.001).\n GC<\/jats:styled-content>\n 24 was slower in\n DD<\/jats:styled-content>\n compared with same\u2010gender healthy controls.\n GC<\/jats:styled-content>\n 24 did not differ among\n DD<\/jats:styled-content>\n females by pregnancy history. Anorectal functions and upper\n GI<\/jats:styled-content>\n transit did not differ among\n DD<\/jats:styled-content>\n patients by colectomy history.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n Patients with\n DD<\/jats:styled-content>\n have slower colonic transit compared with gender\u2010matched controls. Among\n DD<\/jats:styled-content>\n patients, males have higher\n ARP<\/jats:styled-content>\n and\n ASP<\/jats:styled-content>\n , and females have slower colonic transit. Although the clinical significance of these differences may be unclear, findings suggest that interpretation of these tests in suspected\n DD<\/jats:styled-content>\n should be based on same\u2010gender control data.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12095","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T01:54:40Z","timestamp":1360806880000},"page":"502","source":"Crossref","is-referenced-by-count":23,"title":["Interpretation of overall colonic transit in defecation disorders in males and females"],"prefix":"10.1111","volume":"25","author":[{"given":"A.","family":"Shin","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nullens","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Rhee","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. D.","family":"Jeong","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Burton","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.064"},{"key":"e_1_2_10_3_1","first-page":"1471","article-title":"Audit of constipation in a tertiary referral gastroenterology practice","volume":"90","author":"Surrenti E","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301181"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536923"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318231fc64"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01642.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.12.023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03238.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01709.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00526.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.031"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.031"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01344.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00950.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1499-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000410"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.2001.00308.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341215"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01442.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0657-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01441.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199110000-00005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01972.x"},{"key":"e_1_2_10_27_1","first-page":"50","article-title":"Effects of age and sex on anorectal manometry","volume":"80","author":"Loening\u2010Baucke V","year":"1985","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01649702"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.221"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31823fe810"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31823fe7f1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181fd2356"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01069.x"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12095","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:35:31Z","timestamp":1698644131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,14]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/nmo.12095"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12095","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,14]]}}}