{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:35:17Z","timestamp":1789472117748,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our objective is to evaluate the effect of gastric electrical stimulation (<jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content>) on symptoms and quality of life for pediatric patients with functional dyspepsia (FD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients (16 female, median 15\u00a0years) were treated with <jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content> for FD after a median of 24\u00a0months of symptoms (3\u00a0months\u201314\u00a0years). At baseline, 46% required tube feeds and 25% parenteral nutrition. Sixty percent had gastroparesis. The Peds<jats:styled-content style=\"fixed-case\">QL GI<\/jats:styled-content> Module (Peds<jats:styled-content style=\"fixed-case\">QL<\/jats:styled-content>) was completed for 18\/24 both pre\u2010\/post\u2010<jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content> after a median of 8\u00a0months. Patients also completed the Symptom Monitor Worksheet (<jats:styled-content style=\"fixed-case\">SMW<\/jats:styled-content>) pre\u2010\/post\u2010<jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content> after a median of 6\u00a0months. Pre\u2010\/post\u2010<jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content> global health was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Significant improvements were seen in multiple areas of the Peds<jats:styled-content style=\"fixed-case\">QL<\/jats:styled-content>, including stomach pain\/upset, food\/drink limits, heartburn\/reflux, gas\/bloating, patient worry, medication tolerance, and constipation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). A decrease was found in combined symptom severity\/frequency based on <jats:styled-content style=\"fixed-case\">SMW<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Improvements were made in all categories, including vomiting, nausea, early satiety, bloating, fullness, epigastric pain, and burning (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Improvements in Peds<jats:styled-content style=\"fixed-case\">QL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SMW<\/jats:styled-content> scores remained when analysis was limited to normal or delayed gastric emptying (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Thirteen percent needed tube feeds and 13% parenteral nutrition after <jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content>. Sixty\u2010five percent reported that their health was much improved after <jats:styled-content style=\"fixed-case\">GES <\/jats:styled-content><jats:italic>vs<\/jats:italic> 15% the same or worse. Five patients experienced complications, primarily mild abdominal discomfort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In the largest series to date of pediatric patients who have undergone <jats:styled-content style=\"fixed-case\">GES<\/jats:styled-content> for FD, we found significant improvements in upper gastrointestinal symptoms, quality of life, and perception of global health. Patients were less dependent on tube feeding or parenteral nutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12104","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T12:18:43Z","timestamp":1361794723000},"page":"567","source":"Crossref","is-referenced-by-count":41,"title":["Improvement of quality of life and symptoms after gastric electrical stimulation in children with functional dyspepsia"],"prefix":"10.1111","volume":"25","author":[{"given":"P. L.","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Teich","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery The Ohio State University College of Medicine and Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Skaggs","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alhajj","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Mousa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156109.97999.d1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182296033"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40052.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.1.34"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318189694f"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00878-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.12.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04082.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2782-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0096-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31823c9b88"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.10.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.10.028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0818-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00503.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01054.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00748.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018894520557"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01389.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.05.022"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000291905"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283365642"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0586-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.04.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0124-7"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:56:13Z","timestamp":1698677773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/nmo.12104"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12104","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}