{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:57:36Z","timestamp":1723060656591},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Streptozotocin (STZ<\/jats:styled-content>) is known to induce type I diabetes and the loss of the interstitial cells of Cajal (ICC<\/jats:styled-content>). However, the regulation of heme oxygenase\u20101 (HO<\/jats:styled-content>\u20101) expression, which is reported to protect ICC<\/jats:styled-content>, has not yet been elucidated in this model. The aim of this study was to investigate the alterations of HO<\/jats:styled-content>\u20101 expression and clarify the mechanism of ICC<\/jats:styled-content> loss in the stomach using the rat model of STZ<\/jats:styled-content>\u2010induced diabetes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Streptozotocin (65\u00a0mg\u00a0kg\u22121<\/jats:sup>) was intraperitoneally administered to 8\u2010week\u2010old female Wistar rats. Cobalt protoporphyrin (CoPP<\/jats:styled-content>), an HO<\/jats:styled-content>\u20101 inducer, was administered subcutaneously once a week after the STZ<\/jats:styled-content> injection. The expressions of HO<\/jats:styled-content>\u20101 and the receptor tyrosine kinase c\u2010Kit (a marker for ICC<\/jats:styled-content>) proteins were investigated by western blot analysis and immunofluorescence staining.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Expression of c\u2010Kit, particularly in the gastric antrum, was significantly decreased at 8\u00a0weeks, not at 1\u00a0week, compared to those of the control group. Significantly increased induction of HO<\/jats:styled-content>\u20101 expression, especially in the gastric corpus but not in the antrum, was observed in the STZ<\/jats:styled-content> group at 8\u00a0weeks after the STZ<\/jats:styled-content> injection relative to control. CoPP<\/jats:styled-content> administration significantly up\u2010regulated HO<\/jats:styled-content>\u20101 expression in the STZ<\/jats:styled-content> diabetic group and significantly restored the previously reduced ICC<\/jats:styled-content> in the gastric antrum.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Up\u2010regulation of HO<\/jats:styled-content>\u20101 expression in the STZ<\/jats:styled-content> diabetic model was limited to the gastric corpus and impaired up\u2010regulation of HO<\/jats:styled-content>\u20101 expression in the gastric antrum likely induced the disruption of the ICC<\/jats:styled-content> network.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12122","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T03:54:55Z","timestamp":1364442895000},"page":"609","source":"Crossref","is-referenced-by-count":14,"title":["Impaired heme oxygenase\u20101 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin\u2010induced diabetes"],"prefix":"10.1111","volume":"25","author":[{"given":"S.","family":"Mogami","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"},{"name":"TSUMURA Research Laboratories TSUMURA & Co. Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hibi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1909-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01336.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020343"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01444.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70229-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.241bc.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690216"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.12008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01393.2000"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-003-0323-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00288.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652307780363134"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00069.2010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-006-0223-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00487.2006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.06.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2043"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6346fje"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1215-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.12.028"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:56:19Z","timestamp":1698677779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/nmo.12122"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12122","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}