{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:44:19Z","timestamp":1791049459561,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing brain imaging studies have emphasized the role of regional brain activity abnormalities in functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) during the resting state. The goal of this study was to investigate the default mode network (<jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) scanning was carried out on 49 patients and 39 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s. Independent component analysis (<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>) was used to isolate the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> in each subject. Group topography of the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> was compared to study significant alteration in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. A correlation analysis was then performed in the <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> group to investigate the effects of symptom severity and the psychological factors on the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Significant spatial differences with the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients, compared with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s, were mainly found in the dorsomedial prefrontal cortex (dm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>), ventromedial prefrontal cortex (vm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>), orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>), pregenual anterior cingulate cortex (<jats:styled-content style=\"fixed-case\">pACC<\/jats:styled-content>), thalamus, parahippocampal gyrus, precuneus, parietal cortex, and temporal pole. Meanwhile, Nepean Dyspepsia Index (<jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>) scores were positively correlated with the <jats:styled-content style=\"fixed-case\">pACC<\/jats:styled-content>, and was negative correlated with the <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>. However, both the Self\u2010Rating Anxiety Scale (<jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content>) and Self\u2010Rating Depression Scale (<jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content>) scores were not correlated with any regions of interest showing differences between the <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and the <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>These findings suggested that the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> might indeed undergo dysfunctional changes due to the abnormal persistent activity in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients. To a certain extent, the changes in the <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> were related to the <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010related symptom severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12131","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T12:06:50Z","timestamp":1366891610000},"source":"Crossref","is-referenced-by-count":35,"title":["Alterations of the default mode network in functional dyspepsia patients: a resting\u2010state fmri study"],"prefix":"10.1111","volume":"25","author":[{"given":"P.","family":"Liu","sequence":"first","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wen","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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