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Within this circuit, there are multiple subtypes of neurons and glia. Appropriate differentiation of these various cell subtypes is vital for normal <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> function. Studies of the pediatric disorder <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>irschprung's <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">HSCR<\/jats:styled-content>) have provided a number of important insights into the mechanisms and molecules involved in <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content> development; however, there are numerous other <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> disorders that potentially may result from defects in development\/differentiation of only a subset of <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content> neurons or glia. <jats:bold>Purpose<\/jats:bold> Our understanding of the mechanisms and molecules involved in enteric nervous system differentiation is far from complete. Critically, it remains unclear at what point the fates of enteric neural crest cells (<jats:styled-content style=\"fixed-case\">ENCC<\/jats:styled-content>s) become committed to a specific subtype cell fate and how these cell fate choices are made. We will review our current understanding of <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content> differentiation and highlight key questions that need to be addressed to gain a more complete understanding of this biological process.<\/jats:p>","DOI":"10.1111\/nmo.12142","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T09:30:00Z","timestamp":1367487000000},"page":"554-562","source":"Crossref","is-referenced-by-count":6,"title":["Choices choices: regulation of precursor differentiation during enteric nervous system development"],"prefix":"10.1111","volume":"25","author":[{"given":"C.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Biology Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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