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This study was designed to investigate effects and mechanisms of electroacupuncture (<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>) on gastric motility in rats with burns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male rats (intact and vagotomized) were implanted with gastric electrodes, chest and abdominal wall electrodes for investigating the effects of <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> at <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201036 (stomach\u201036 or Zusanli) on <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>, gastric slow waves, autonomic functions, and plasma interleukin 6 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) 6 and 24\u00a0h post severe burns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>(i) Burn delayed <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> (P\u00a0&lt;\u00a00.001). Electroacupuncture improved <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> 6 and 24\u00a0h post burn (P\u00a0&lt;\u00a00.001). Vagotomy blocked the <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> effect on <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>. (ii) Electroacupuncture improved burn\u2010induced gastric dysrhythmia. The percentage of normal slow waves was increased with <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> 6 and 24\u00a0h post burn (P\u00a0=\u00a00.02). (iii) Electroacupuncture increased vagal activity assessed by the spectral analysis of heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>). The high\u2010frequency component reflecting vagal component was increased with <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content> 6 (P\u00a0=\u00a00.004) and 24\u00a0h post burn (P\u00a0=\u00a00.03, <jats:italic>vs<\/jats:italic> sham\u2010<jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>). (iv) Electroacupuncture attenuated burn\u2010induced increase in plasma <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 at both 6 (P\u00a0=\u00a00.03) and 24\u00a0h post burn (P\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Electroacupuncture at <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201036 improves gastric dysrhythmia and accelerates <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> in rats with burns. The improvement seems to be mediated via the vagal pathway involving the inflammatory cytokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12183","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T10:28:13Z","timestamp":1373624893000},"page":"807","source":"Crossref","is-referenced-by-count":49,"title":["Electroacupuncture improves burn\u2010induced impairment in gastric motility mediated via the vagal mechanism in rats"],"prefix":"10.1111","volume":"25","author":[{"given":"J.","family":"Song","sequence":"first","affiliation":[{"name":"Division of Gastroenterology University of Texas Medical Branch Galveston TX USA"},{"name":"Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Texas Medical Branch Galveston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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