{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:37:21Z","timestamp":1754397441311,"version":"3.40.4"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Substance P (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) is a member of the neurokinin (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) family and is one of the established neurotransmitters in the mammalian central and enteric nervous system. It is unclear whether<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>1 receptors are involved in the control of gastric sensorimotor function in man.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the effects of aprepitant, an<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>1 receptor antagonist used in the treatment of chemotherapy\u2010induced emesis, on gastric sensorimotor function in healthy volunteers. Sixteen healthy volunteers (six males, 32.4\u00a0\u00b1\u00a02.7 years) were studied on three separate occasions after placebo, aprepitant 80 or 125\u00a0mg in randomized double\u2010blind study to assess gastric compliance, perception to isobaric distensions, and gastric accommodation with a gastric barostat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Compared to placebo, both doses of aprepitant did not influence gastric compliance or sensitivity to gastric distension. Aprepitant 80 and 125\u00a0mg did not have any significant effects on gastric accommodation compared with placebo (mean postprandial gastric volume increase, respectively, 83.4\u00a0\u00b1\u00a028.4<jats:italic>vs<\/jats:italic>35.3\u00a0\u00b1\u00a016.2<jats:italic>vs<\/jats:italic>83.9\u00a0\u00b1\u00a030.4\u00a0mL,<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). Postprandial gastric compliance and sensitivity to distention were also not altered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In health,<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>1 receptors do not appear to be involved in the control of gastric compliance, accommodation or sensitivity to distention in man.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12210","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T10:04:48Z","timestamp":1378116288000},"source":"Crossref","is-referenced-by-count":6,"title":["Influence of a neurokinin\u20101 receptor antagonist (aprepitant) on gastric sensorimotor function in healthy volunteers"],"prefix":"10.1111","volume":"25","author":[{"given":"D.","family":"Ang","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven 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