{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:16:18Z","timestamp":1792700178902,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low basal lower esophageal sphincter (<jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>) pressure and transient <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content> relaxations are major causes of gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>). Pumosetrag, a novel selective partial 5<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 receptor agonist, showed a promising effect on reducing reflux events in health. We aimed to evaluate the effect of pumosetrag on changes in reflux episodes, lower esophageal sphincter pressure (<jats:styled-content style=\"fixed-case\">LESP<\/jats:styled-content>), and specific symptoms in patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> receiving a refluxogenic meal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, who developed heartburn and\/or regurgitation after ingestion of a refluxogenic meal, were randomized to 1 of 3 dose levels of pumosetrag (0.2, 0.5, or 0.8\u00a0mg) or placebo. Before and after 7\u00a0days of treatment, patients underwent manometry, intraesophageal multichannel, intraluminal impedance and pH after a standard refluxogenic meal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 223 patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> [125 (56%) women, mean (SD) age\u00a0=\u00a036 (12) years] were enrolled. No overall treatment effects were detected for the total number of reflux episodes (acidic and weakly acidic) (p\u00a0&gt;\u00a00.5); however, significant treatment effects (p\u00a0&lt;\u00a00.05) on the number of acid reflux episodes were observed with lower values on pumosetrag 0.2\u00a0mg (10.8\u00a0\u00b1\u00a01.1), 0.5\u00a0mg (9.5\u00a0\u00b1\u00a01.1), and 0.8\u00a0mg (9.9\u00a0\u00b1\u00a01.1) compared with placebo (13.3\u00a0\u00b1\u00a01.1). Significant treatment effects (p\u00a0&lt;\u00a00.05) were also observed for the percentage of time pH was &lt;4, with less time for pumosetrag at 0.5\u00a0mg (10%) and 0.8\u00a0mg (10%) compared with placebo (16%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, the partial 5<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 agonist pumosetrag significantly reduced the rate of acid reflux events but did not result in a significant change in <jats:styled-content style=\"fixed-case\">LESP<\/jats:styled-content> or symptomatic improvement over a 1\u2010week treatment period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12214","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T04:49:09Z","timestamp":1378270149000},"page":"13-20","source":"Crossref","is-referenced-by-count":7,"title":["Novel partial 5<scp>HT<\/scp>3 agonist pumosetrag reduces acid reflux events in uninvestigated <scp>GERD<\/scp> patients after a standard refluxogenic meal: a randomized, double\u2010blind, placebo\u2010controlled pharmacodynamic study"],"prefix":"10.1111","volume":"26","author":[{"given":"R. S.","family":"Choung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"},{"name":"Division of Gastroenterology and Hepatology Korea University College of Medicine Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"G. R.","family":"Locke","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Francis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Winkle","sequence":"additional","affiliation":[{"name":"Advanced Clinical Research Institute Anaheim CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. C.","family":"Orr","sequence":"additional","affiliation":[{"name":"Lynn Health Science Institute Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Crowell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"DeVault","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. S.","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41217.x"},{"key":"e_1_2_10_5_1","first-page":"CD003244","article-title":"Medical treatments in the short term management of reflux oesophagitis","volume":"18","author":"Khan M","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68932-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00317-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1996.tb00253.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00817.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02238.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01153.x"},{"key":"e_1_2_10_13_1","first-page":"416","article-title":"Drug evaluation: pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease","volume":"8","author":"Evangelista S","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109984"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"A731","article-title":"The effect of a novel 5\u2010HT3 receptor partial agonist (DDP733) on feline esophageal peristalsis and lower esophageal sphincter pressure","volume":"130","author":"Venkova K","year":"2006","journal-title":"Gastroenterology"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2005.00695.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01797.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03591.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1155\/2008\/737062","article-title":"High\u2010resolution esophageal manometry: a time motion study","volume":"22","author":"Sadowski DC","year":"2008","journal-title":"Can J Gastroenterol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24840"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00661.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"issue":"747","key":"e_1_2_10_24_1","first-page":"e350","article-title":"PPI therapy is equally effective in well\u2010defined non\u2010erosive reflux disease and in reflux esophagitis: a meta\u2010analysis","volume":"24","author":"Weijenborg PW","year":"2012","journal-title":"Neurogastroenterol Motil"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:45:25Z","timestamp":1696221925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,3]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/nmo.12214"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12214","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,3]]}}}