{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:15:22Z","timestamp":1791411322886,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) with mixed bowel habits (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M) is a heterogeneous subtype with varying symptoms of constipation and diarrhea, and has not been well characterized. We aimed to characterize gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M patients from a US patient population, and to compare them with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> with constipation (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C) and diarrhea (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects answering community advertisements and meeting Rome III criteria for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> completed symptom questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of the initial 289 <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients identified, one third (n\u00a0=\u00a051, 32.5%) who met Rome III criteria for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M endorsed having either loose stools or hard stools due to medication. These patients had more severe symptoms and longer duration of flares compared to the rest of the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M group (p\u00a0=\u00a00.014, p\u00a0=\u00a00.005). Excluding <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M patients with medication\u2010related extremes in stool form who could not be reclassified by medical history, 247 <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients were assessed. <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M was the most common (44.1%), followed by <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C (27.9%), <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D (26.3%), and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010U (unsubtyped, 1.6%). While <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M shared symptoms with both <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D, there were significant differences in the prevalence of bowel habit symptoms (p\u2010value range: &lt;0.001\u20130.002). <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M patients reported most bothersome symptoms that were more similar to <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D, with the most common being irregular bowel habits (27.5%), bloating (26.6%), and abdominal pain (20.2%). There were no differences in non\u2010<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms between subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M is a heterogeneous symptom group and thus requires that subclassification criteria be better defined. Use of laxative\/antidiarrheal medications adds to the diagnostic complexity in a potentially more severe subset of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010M and should be assessed for accurate subclassification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12220","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T10:24:58Z","timestamp":1377771898000},"page":"36-45","source":"Crossref","is-referenced-by-count":39,"title":["Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern"],"prefix":"10.1111","volume":"26","author":[{"given":"A. M.","family":"Su","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago IL USA"},{"name":"Department of Medicine Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Biostatistics UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Presson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics UCLA Los Angeles CA USA"},{"name":"Department of Internal Medicine University of Utah Salt Lake City UT USA"},{"name":"Department of Pediatrics University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200302000-00010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01456.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0295-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_10_8_1","volume-title":"Rome II: The Functional Gastrointestinal Disorders","author":"Drossman DA","year":"2000"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6722.439"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.10.1455"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41211.x"},{"key":"e_1_2_10_12_1","first-page":"427","article-title":"[Prevalence and clinical characteristics of the IBS subtypes according to the Rome III criteria in patients from a clinical, multicentric trial. 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