{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:00:06Z","timestamp":1785769206374,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T00:00:00Z","timestamp":1380067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Irritable bowel syndrome (IBS<\/jats:styled-content>) impairs quality of life (HRQOL<\/jats:styled-content>), as does systemic lupus erythematosus (SLE<\/jats:styled-content>). Both are more common in women and are associated with fibromyalgia (FM<\/jats:styled-content>). However, the relationship between IBS<\/jats:styled-content> and SLE<\/jats:styled-content> and its impact on HRQOL<\/jats:styled-content> has not been explored. Therefore, we aimed to study the frequency and features likely to influence the presence of IBS<\/jats:styled-content>\u2010type symptoms in SLE<\/jats:styled-content> and their impact on HRQOL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Female patients with SLE<\/jats:styled-content> were studied. The presence of IBS<\/jats:styled-content>\u2010type symptoms and bowel habit subtype were established by Rome III criteria and HRQOL<\/jats:styled-content> was assessed using the SF<\/jats:styled-content>\u201036. Fibromyalgia and depression were assessed using the A<\/jats:styled-content>merican C<\/jats:styled-content>ollege of R<\/jats:styled-content>heumatology criteria and CES<\/jats:styled-content>\u2010D scale, respectively.<\/jats:p><\/jats:sec>Key Results<\/jats:title>A total of 105 consecutive patients (43.62\u00a0\u00b1\u00a011.34 years old) were included; 48.6% had IBS<\/jats:styled-content>\u2010type symptoms (SLE<\/jats:styled-content>+IBS<\/jats:styled-content>) and were classified as IBS<\/jats:styled-content>\u2010C: 23.5%, IBS<\/jats:styled-content>\u2010D: 37.3%, and IBS<\/jats:styled-content>\u2010M: 39.2%. In addition, 23.8% had FM<\/jats:styled-content>. SLE<\/jats:styled-content>+IBS<\/jats:styled-content> vs Non\u2010IBS SLE<\/jats:styled-content> patients had higher SLE<\/jats:styled-content> activity scores (2.55\u00a0\u00b1\u00a01.65 vs 1.74\u00a0\u00b1\u00a02.19; p\u00a0=\u00a00.03), were more likely to have FM<\/jats:styled-content> (33.0% vs 14.8%; p\u00a0=\u00a00.02) and depression (41.1% vs 25.9%, p\u00a0=\u00a00.04). Logistic multivariate analysis showed that IBS<\/jats:styled-content>\u2010type symptoms were associated with FM<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a02.85, 95% CI<\/jats:styled-content>: 1.11\u20137.43) and depression (OR<\/jats:styled-content>\u00a0=\u00a01.07, 95% CI<\/jats:styled-content>: 1.02\u20131.13). Finally, SLE<\/jats:styled-content>+IBS<\/jats:styled-content> vs Non\u2010IBS SLE<\/jats:styled-content> patients had lower SF<\/jats:styled-content>\u201036 scores (49.65\u00a0\u00b1\u00a018.57 vs 62.67\u00a0\u00b1\u00a018.14; p\u00a0=\u00a00.02).<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>IBS<\/jats:styled-content>\u2010type symptoms are highly prevalent among women with SLE<\/jats:styled-content> and are associated with FM<\/jats:styled-content> and depression. SLE<\/jats:styled-content>+IBS<\/jats:styled-content> patients had worse HRQOL<\/jats:styled-content> vs Non\u2010IBS SLE<\/jats:styled-content>, independently of FM<\/jats:styled-content> status. We suggest that treating IBS<\/jats:styled-content> symptoms may improve HRQOL<\/jats:styled-content> in women with SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12230","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:23:29Z","timestamp":1381530209000},"page":"958-966","source":"Crossref","is-referenced-by-count":12,"title":["Irritable bowel syndrome\u2010type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Garc\u00eda Carrasco","sequence":"first","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit Hospital General Regional No. 36, Instituto Mexicano del Seguro Social Puebla Puebla M\u00e9xico"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente Instituto Mexicano del Seguro Social Metepec Puebla M\u00e9xico"},{"name":"Immunology and Rheumatology Medicine 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Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit Hospital General Regional No. 36, Instituto Mexicano del Seguro Social Puebla Puebla M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Andari Sawaya","sequence":"additional","affiliation":[{"name":"Medicine Department Temple University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mu\u00f1oz Guarneros","sequence":"additional","affiliation":[{"name":"Research and Postgraduate Department Medicine School Ben\u00e9merita Universidad Aut\u00f3noma de Puebla Puebla Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"V\u00e1zquez De Lara","sequence":"additional","affiliation":[{"name":"Research and Postgraduate Department Medicine School Ben\u00e9merita Universidad Aut\u00f3noma de Puebla Puebla Puebla 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