{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:22:21Z","timestamp":1777040541024,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nausea and vomiting are thought to result from upper gastrointestinal dysfunctions. Our clinical observations led to the hypothesis that colonic motor dysfunction is associated with nausea and vomiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed electronic medical records (<jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>) of 149 patients presenting with complaints of nausea and\/or vomiting in a tertiary gastroenterology practice to investigate the association with disorders of colonic motor or evacuation disorders. We extracted demographics, gastric emptying (<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>in 149) and colonic transit (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>in 138) of solids, ascending colon emptying half\u2010time (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content><jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>), rectal evacuation by anorectal manometry (<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>) in 91 and balloon expulsion test (<jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>) in 55 patients. We estimated the proportions with delayed<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, based on the 5th percentile of<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>(in 319) and<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>in 220 healthy volunteers using same method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among 11 patients with nausea and\/or vomiting with only<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>measured, five had delayed and six normal<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>. Among the 149 patients, 77 (52%) patients had evacuation disorders, confirmed by objective tests in 68 patients, and clinical examination in nine patients. In the 138 patients with both<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>measured, 106 (76%) had both normal<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, 11 (8%) only delayed<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>, 16 (11%) normal<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>with delayed<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, and five (3%) delayed<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Among 21 patients (15%) with delayed<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, nine had slow<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content><jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>and 12 evacuation disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In patients with chronic nausea and\/or vomiting in gastroenterology practice, evaluation of colonic motility and rectal evacuation should be considered, since about half the patients have abnormal functions that conceivably contribute to the presenting nausea and\/or vomiting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12242","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:42:34Z","timestamp":1381545754000},"page":"131-138","source":"Crossref","is-referenced-by-count":54,"title":["Prevalence of colonic motor or evacuation disorders in patients presenting with chronic nausea and vomiting evaluated by a single gastroenterologist in a tertiary referral practice"],"prefix":"10.1111","volume":"26","author":[{"given":"G. J.","family":"Kolar","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Burton","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00153-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)00130-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.199"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00581.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04162.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01295908"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.01.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020995"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301181"},{"key":"e_1_2_11_13_1","first-page":"93","article-title":"Evaluation of an inexpensive screening scintigraphic test of gastric emptying","volume":"36","author":"Thomforde GM","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01972.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01344.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01441.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.23"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00499.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01069.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710109"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199110000-00005"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91092-I"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050015"},{"key":"e_1_2_11_24_1","first-page":"1471","article-title":"Audit of constipation in a tertiary referral gastroenterology practice","volume":"90","author":"Surrenti E","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00950.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0657-4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03195.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00454-9"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0031-6997(25)07328-4","article-title":"Physiology and pharmacology of vomiting","volume":"5","author":"Borison HL","year":"1953","journal-title":"Pharmacol Rev"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312478"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00463.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318231fc64"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T16:47:51Z","timestamp":1746031671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,10]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/nmo.12242"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12242","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,10]]}}}