{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:17:49Z","timestamp":1789712269804,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Previous assessments of colon morphology have relied on tests which were either invasive or used ionizing radiation. We aimed to measure regional volumes of the undisturbed colon in healthy volunteers (\n HV<\/jats:styled-content>\n ) and patients with diarrhea\u2010predominant irritable bowel syndrome (\n IBS<\/jats:styled-content>\n \u2010D).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 3D regional (ascending, transverse, and descending) colon volumes were measured in fasting abdominal magnetic resonance (\n MR<\/jats:styled-content>\n ) images of 75\n HV<\/jats:styled-content>\n s and 25\n IBS<\/jats:styled-content>\n \u2010D patients. Thirty\u2010five of the\n HV<\/jats:styled-content>\n and all 25\n IBS<\/jats:styled-content>\n \u2010D subjects were fed a standard meal and postprandial\n MRI<\/jats:styled-content>\n data obtained over 225\u00a0min.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Colonic regions were identified and 3D maps from cecum to sigmoid flexure were defined. Fasted regional volumes showed wide variation in both\n HV<\/jats:styled-content>\n s being (mean\u00a0\u00b1\u00a0\n SD<\/jats:styled-content>\n ) ascending colon (\n AC<\/jats:styled-content>\n ) 203\u00a0\u00b1\u00a075\u00a0mL, transverse (\n TC<\/jats:styled-content>\n ) 198\u00a0\u00b1\u00a079\u00a0mL, and descending (\n DC<\/jats:styled-content>\n ) 160\u00a0\u00b1\u00a086\u00a0mL with no difference from\n IBS<\/jats:styled-content>\n \u2010D subjects (\n AC<\/jats:styled-content>\n 205\u00a0\u00b1\u00a069\u00a0mL,\n TC<\/jats:styled-content>\n 232\u00a0\u00b1\u00a0100\u00a0mL, and\n DC<\/jats:styled-content>\n 151\u00a0\u00b1\u00a071\u00a0mL, respectively). The\n AC<\/jats:styled-content>\n volume expanded by 10% after feeding (p\u00a0=\u00a00.007) in the 35\n HV<\/jats:styled-content>\n possibly due to increased ileo\u2010colonic inflow. A later rise in\n AC<\/jats:styled-content>\n volume occurred from t\u00a0=\u00a090 to t\u00a0=\u00a0240\u00a0min as the meal residue entered the cecum. In contrast,\n IBS<\/jats:styled-content>\n \u2010D subjects showed a much reduced postprandial response of the\n AC<\/jats:styled-content>\n (p\u00a0<\u00a00.0001) and a greater increase in\n TC<\/jats:styled-content>\n volume after 90\u00a0min (p\u00a0=\u00a00.0244) compared to\n HV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n We have defined a normal range of the regional volumes of the undisturbed colon in fasted and fed states. The\n AC<\/jats:styled-content>\n in\n IBS<\/jats:styled-content>\n \u2010D appeared less able to accommodate postprandial inflow which may account for faster colonic transit.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12243","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T04:01:34Z","timestamp":1381982494000},"page":"124-130","source":"Crossref","is-referenced-by-count":122,"title":["Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea\u2010predominant irritable bowel syndrome measured using serial\n MRI<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"S. E.","family":"Pritchard","sequence":"first","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marciani","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Clinical Sciences University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Garsed","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Hoad","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Thongborisute","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Clinical Sciences University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Clinical Sciences University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Gowland","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Spiller","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Clinical Sciences University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.12.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2010.24"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(02)00418-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4950.1243"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-002-0057-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00346222"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01794949"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214899"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.03.054"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00808416"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05127.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(12)63166-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)63428-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302514a.90"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.055"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91789-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.5.405"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60796-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90080-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90079-Z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01597.x"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.12243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:45:14Z","timestamp":1696207514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/nmo.12243"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12243","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718146861.793485917","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}