{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:36:44Z","timestamp":1790041004267,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite chronic pain being a feature of functional chest pain (<jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content>) its experience is variable. The factors responsible for this variability remain unresolved. We aimed to address these knowledge gaps, hypothesizing that the psychophysiological profiles of <jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content> patients will be distinct from healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>20 Rome III defined <jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content> patients (nine males, mean age 38.7\u00a0years, range 28\u201359\u00a0years) and 20 healthy age\u2010, sex\u2010, and ethnicity\u2010matched controls (nine males, mean 38.2\u00a0years, range 24\u201349) had anxiety, depression, and personality traits measured. Subjects had sympathetic and parasympathetic nervous system parameters measured at baseline and continuously thereafter. Subjects received standardized somatic (nail bed pressure) and visceral (esophageal balloon distension) stimuli to pain tolerance. Venous blood was sampled for cortisol at baseline, post somatic pain and post visceral pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Patients had higher neuroticism, state and trait anxiety, and depression scores but lower extroversion scores vs controls (all p\u00a0&lt;\u00a00.005). Patients tolerated less somatic (p\u00a0&lt;\u00a00.0001) and visceral stimulus (p\u00a0=\u00a00.009) and had a higher cortisol at baseline, and following pain (all p\u00a0&lt;\u00a00.001). At baseline, patients had a higher sympathetic tone (p\u00a0=\u00a00.04), whereas in response to pain they increased their parasympathetic tone (p\u00a0\u2264\u00a00.008). The amalgamating the data, we identified two psychophysiologically distinct \u2018pain clusters\u2019. Patients were overrepresented in the cluster characterized by high neuroticism, trait anxiety, baseline cortisol, pain hypersensitivity, and parasympathetic response to pain (all p\u00a0&lt;\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In future, such delineations in <jats:styled-content style=\"fixed-case\">FCP<\/jats:styled-content> populations may facilitate individualization of treatment based on psychophysiological profiling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12245","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T11:19:01Z","timestamp":1382095141000},"page":"139-148","source":"Crossref","is-referenced-by-count":47,"title":["Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters"],"prefix":"10.1111","volume":"26","author":[{"given":"A. D.","family":"Farmer","sequence":"first","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Coen","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"},{"name":"Department of Neuroimaging Institute of Psychiatry King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kano","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"},{"name":"Behavioural Medicine Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Paine","sequence":"additional","affiliation":[{"name":"Gastrointestinal Sciences University of Manchester Manchester UK"},{"name":"Salford Royal Foundation NHS Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Scott","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Furlong","sequence":"additional","affiliation":[{"name":"Aston Brain Centre School of Life and Health Sciences Aston University Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Lightman","sequence":"additional","affiliation":[{"name":"Henry Wellcome Laboratories for Integrative Neuroscience &amp; Endocrinology University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Centre for Digestive Diseases Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Rome III: The Functional Gastrointestinal Disorders","author":"Drossman DA","year":"2006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.09.013"},{"key":"e_1_2_10_4_1","volume-title":"Bonica's Management of Pain","author":"Ballantyne J","year":"2009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90685-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01451.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-11-199606010-00002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06068.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.706"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170000307X"},{"key":"e_1_2_10_11_1","first-page":"11","article-title":"The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors","volume":"88","author":"Bradley LA","year":"1993","journal-title":"The American journal of gastroenterology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.88.4.369"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.022"},{"key":"e_1_2_10_16_1","volume-title":"Manual for the state\/trait anxiety inventory (form Y): (self evaluation questionnaire)","author":"Spielberger CD","year":"1983"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141204"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200206000-00006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511546396"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1992.tb00368.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.036715"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0942"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-709X-20-20"},{"key":"e_1_2_10_25_1","unstructured":"BacherJ.SPSS twostep cluster: a first evaluation 2004. Available at:http:\/\/wwwstatisticalinnovationscom\/products\/twosteppdf. Accessed October 2012."},{"key":"e_1_2_10_26_1","unstructured":"University of Leon.http:\/\/www.unileon.es\/ficheros\/servicios\/informatica\/spss\/english\/IBM-SPSS_basico.pdf. Accessed October 2012."},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01348.x"},{"key":"e_1_2_10_28_1","unstructured":"DolnicarS.A review of unquestioned standards in using cluster analysis for data\u2010driven market segmentation. Proceedings of the Australian and New Zealand Marketing Academy Conference 2002 CD Conference (ANZMAC 2002)2002. University of Wollongong. Available athttp:\/\/ro.uow.edu.au\/cgi\/viewcontent.cgi?article=1286&context=commpapers Accessed October 2012."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029600500205"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.02.010"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3844\/jcssp.2008.252.255"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04101.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.021"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.047"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(99)00032-X"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199512000-00006"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01711.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2006.09.001"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.02.002"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01385.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.08.027"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.239301.53"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0217"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/0097-7403.34.1.75"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90341-4"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01171.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.023"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.053"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.10.001"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.049"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30040.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:45:20Z","timestamp":1696221920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/nmo.12245"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12245","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}