{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:12Z","timestamp":1761895812613},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcutaneous electrical tibial nerve stimulation (<jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>) is of growing interest for the treatment of fecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>), but its mechanism of action remains uninvestigated. We aimed to further assess the anorectal response to <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> in a dynamic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a placebo\u2010controlled, randomized, double\u2010blinded crossover study in 19 patients suffering from <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> to assess the effects of <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> on anorectal function. Anorectal physiology and perception were recorded through two sequences of rectal isobaric distension using an electronic barostat device to measure anal and rectal pressures, rectal volumes, and perception scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Maximal rectal pressure and volume variation were affected by <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>, with higher mean maximal rectal pressure (5.33 and 4.06\u00a0mmHg in the active and sham <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and lower volume variation (11.45 and 14.7\u00a0mL in the active and sham stimulation respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Rectal compliance was not modified by active <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>. Pressure of the upper anal canal was significantly lower with raised isobaric distension in sequences assigned to active <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Acute <jats:styled-content style=\"fixed-case\">TENS<\/jats:styled-content> modified anorectal physiology by strengthening the myogenic response to distension rather than increasing muscle relaxation and related rectal compliance in patients with <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12256","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T04:03:40Z","timestamp":1390190620000},"page":"247-254","source":"Crossref","is-referenced-by-count":11,"title":["Effects of transcutaneous tibial nerve stimulation on anorectal physiology in fecal incontinence: a double\u2010blind placebo\u2010controlled cross\u2010over evaluation"],"prefix":"10.1111","volume":"26","author":[{"given":"G.","family":"Bouguen","sequence":"first","affiliation":[{"name":"Service des Maladie de l'Appareil Digestif Centre Hospitalier Pontchaillou et Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ropert","sequence":"additional","affiliation":[{"name":"Service des Explorations Fonctionnelles Centre Hospitalier Pontchaillou et universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lain\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'investigation Clinique Centre Hospitalier Pontchaillou et universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pequin","sequence":"additional","affiliation":[{"name":"Service des Explorations 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