{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:28:02Z","timestamp":1790969282603,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Anatomical structures and their distensibility vary along the length of the anal canal. The anal sphincter muscles have dynamic properties that are not well\u2010reflected by standard manometry. Abnormal distensibility of the anal canal may be of importance in idiopathic fecal incontinence (\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      ). The functional lumen imaging probe (\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      ) allows detailed studies of the distensibility and axial variation of sphincters. We aimed at comparing segmental distensibility of the anal canal in patients with\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      and healthy subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      was used for distension of the anal canal in 22 patients with\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      (17 female, age 27\u201382\u00a0years) and 21 healthy volunteers (18 female, age 32\u201373\u00a0years). The distensibility was determined from changes in luminal diameter. Closure of the anal canal during voluntary squeeze was computed as the combined length of closed anal canal and time. Pressure\u2010strain elastic modulus was computed at rest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      In all subjects, the proximal anal canal was the most distensible segment. During distension at rest and during squeeze the middle and distal anal canal became significantly larger in\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      than in healthy (F\u00a0&lt;\u00a022.4, p\u00a0&lt;\u00a00.05). The closure of the anal canal during voluntary squeeze did not differ between healthy (75.9\u00a0\u00b1\u00a092.9\u00a0mm\u00a0s) and\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      patients (90.4\u00a0\u00b1\u00a0105\u00a0mm\u00a0s; p\u00a0=\u00a00.6). Compared with healthy,\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      patients had lower pressure\u2010strain elastic modulus of the middle and distal (q\u00a0&gt;\u00a04.5, p\u00a0&lt;\u00a00.05) but not the proximal anal canal (q\u00a0&lt;\u00a00.7, p\u00a0&gt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Patients with\n                      <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>\n                      have increased distensibility of the middle and distal parts of the anal canal.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12258","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T02:03:02Z","timestamp":1385690582000},"page":"255-263","source":"Crossref","is-referenced-by-count":53,"title":["Distensibility of the anal canal in patients with idiopathic fecal incontinence: a study with the Functional Lumen Imaging Probe"],"prefix":"10.1111","volume":"26","author":[{"given":"G.","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Surgery P Pelvic Floor Unit Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liao","sequence":"additional","affiliation":[{"name":"Clinical Institute Aarhus University Hospital Aarhus Denmark"},{"name":"Mech\u2010Sense Department of Gastroenterology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lundby","sequence":"additional","affiliation":[{"name":"Department of Surgery P Pelvic Floor Unit Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fynne","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Department of Surgery P Pelvic Floor Unit Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gregersen","sequence":"additional","affiliation":[{"name":"College of Bioengineering Chongqing University China and the GIOME Institute Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Department of Surgery P Pelvic Floor Unit Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,29]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","volume-title":"Faecal Incontinence\u2010 The Management of Faecal Incontinence in Adults","author":"Norton 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