{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:26:12Z","timestamp":1772605572001,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Real\u2010life data on the economic burden of chronic idiopathic constipation are scarce. The objectives of this study were to assess hospitalization resource use and costs associated with chronic constipation and its complications in Belgium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single country, retrospective study using the <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> Hospital Disease Database (2008), which comprises data on 34% of acute hospital beds in Belgium and contains information on patient demographics, length of stay (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>), billed costs, drug use, diagnoses, and procedures. Stays with a primary diagnosis of constipation, or a secondary diagnosis of constipation and a concomitant diagnosis of a constipation\u2010related complication, were selected. Patients with diagnoses of colorectal cancer, ulcerative colitis or Crohn's disease, or who had stays involving potentially constipation\u2010inducing procedures, were excluded as having secondary constipation. Patients receiving opioids, calcium\u2010antagonists, antipsychotics or antidepressants were excluded as having drug\u2010induced constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In total, 1541 eligible patients were identified. The average unadjusted cost per day in hospital for idiopathic constipation was \u20ac441 (\u20ac311\u00a0\u00b1\u00a01.4 in day clinic visits without overnight stays; \u20ac711\u00a0\u00b1\u00a014.0 in full hospitalizations with complications). The average <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> in a full hospitalization setting was 7.0 and 4.0\u00a0days in stays with and without complications, respectively. The most frequent drug and procedural treatments were osmotically acting laxatives (with complications: 42.61%; without complications: 35.69%), and transanal enema (2.32% and 2.03%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The burden of constipation is often underestimated; it is a condition reflected by hospital\u2010related costs comparable to such indications as migraine, which increase when associated with complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12269","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T10:36:44Z","timestamp":1386758204000},"page":"368-376","source":"Crossref","is-referenced-by-count":10,"title":["In\u2010hospital costs associated with chronic constipation in Belgium: a retrospective database study"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Chevalier","sequence":"first","affiliation":[{"name":"Health Economics and Outcome Research IMS Health HEOR Vilvoorde Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lamotte","sequence":"additional","affiliation":[{"name":"Health Economics and Outcome Research IMS Health HEOR Vilvoorde Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Global Health Economic and Outcome Research, Research and Development Shire Nyon Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dubois","sequence":"additional","affiliation":[{"name":"ULB PHARMED (Post\u2010Graduate Programme in Pharmaceutical Medicine &amp; Medicines Development Sciences) Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Boeckxstaens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven University Hospital of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.40"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.011"},{"key":"e_1_2_11_6_1","unstructured":"Rome III diagnostic criteria for functional gastrointestinal disorders.2006. 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