{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:15Z","timestamp":1787015835305,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The endogenous cannabinoid system (\n ECS<\/jats:styled-content>\n ) plays a crucial role in multiple physiological processes in the central nervous system and in the periphery. The discovery that selective cannabinoid (\n CB<\/jats:styled-content>\n ) receptor agonists exert a potent inhibitory action on gastrointestinal (\n GI<\/jats:styled-content>\n ) motility and pain has placed the\n ECS<\/jats:styled-content>\n in the center of attention as a possible target for the treatment of functional\n GI<\/jats:styled-content>\n diseases. However, side effects of\n CB<\/jats:styled-content>\n agonists prompted the search for novel therapeutic targets. Here, the effect of\n PF<\/jats:styled-content>\n \u20103845, a potent and selective fatty acid amide hydrolase (\n FAAH<\/jats:styled-content>\n ) inhibitor in the\n GI<\/jats:styled-content>\n tract was investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The effect of\n PF<\/jats:styled-content>\n \u20103845 on\n GI<\/jats:styled-content>\n motility was characterized in vitro and in vivo, using mouse models that mimic physiological and pathophysiological conditions. The antinociceptive action of\n PF<\/jats:styled-content>\n \u20103845 was evaluated on the basis of behavioral pain models. Endocannabinoid degradation product levels after inhibition of\n FAAH<\/jats:styled-content>\n were quantified using\n HPLC<\/jats:styled-content>\n \u2010\n MS<\/jats:styled-content>\n \/\n MS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n PF<\/jats:styled-content>\n \u20103845 significantly inhibited mouse colonic motility in vitro and in vivo. Selective inhibition of\n FAAH<\/jats:styled-content>\n reversed hypermotility and reduced pain in mouse models mimicking functional\n GI<\/jats:styled-content>\n disorders. The effects of\n PF<\/jats:styled-content>\n \u20103845 were mediated by endogenous\n CB<\/jats:styled-content>\n s and non\u2010\n CB<\/jats:styled-content>\n lipophilic compounds via classical (\n CB<\/jats:styled-content>\n 1) and atypical\n CB<\/jats:styled-content>\n receptors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n These data expand our understanding of the\n ECS<\/jats:styled-content>\n function and provide a novel framework for the development of future potential treatments of functional\n GI<\/jats:styled-content>\n disorders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12272","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T06:28:45Z","timestamp":1386138525000},"page":"470-481","source":"Crossref","is-referenced-by-count":60,"title":["Selective inhibition of\n FAAH<\/scp>\n produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid\u2010like fatty acid amides"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"Fichna","sequence":"first","affiliation":[{"name":"Snyder Institute for Chronic Diseases University of Calgary Calgary AB Canada"},{"name":"Department of Medicine Division of Gastroenterology University of Calgary Calgary AB Canada"},{"name":"Department of Biomolecular Chemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sa\u0142aga","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Gill Center for Biomolecular Science Indiana University Bloomington IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Saur","sequence":"additional","affiliation":[{"name":"II Medizinische Klinik Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sobczak","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zatorski","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. \u2010P.","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Histology Department of Veterinary Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Gill Center for Biomolecular Science Indiana University Bloomington IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Pfizer Worldwide Research and Development Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Storr","sequence":"additional","affiliation":[{"name":"Snyder Institute for Chronic Diseases University of Calgary Calgary AB Canada"},{"name":"Department of Medicine Division of Gastroenterology University of Calgary Calgary AB Canada"},{"name":"Department of Medicine Division of Gastroenterology Ludwig Maximilians University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.12.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01175.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.08.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear 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