{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:43:38Z","timestamp":1791499418404,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic megacolon (<jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content>) is an intractable motility disorder in which chronic symptoms of colonic dysmotility appear with no mechanical cause. Although a pathological analysis is essential to understand the mechanism of <jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content>, no study has compared the histopathologic findings between dilated and non\u2010dilated loops in <jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content> cases, and little is known about the proportion of each disease subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three full\u2010thickness samples (dilated loops, n\u00a0=\u00a031; non\u2010dilated loops, n\u00a0=\u00a022) from 31 <jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content> cases and 16 samples (dilated loops; n\u00a0=\u00a08, non\u2010dilated loops; n\u00a0=\u00a08) from eight controls were collected. All the samples were stained with hematoxylin\u2010eosin (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>), Hu C\/D antibody, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117 antibody to assess degenerative myopathy, degenerative neuropathy, inflammatory neuropathy, hypoganglionosis, and mesenchymopathy according to the London Classification. Findings of the dilated and non\u2010dilated loop samples were compared, and the proportions of each subtype were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Based on a control study, &lt;60 ganglion cells\/cm was defined as hypoganglionosis in our series. Myopathy was observed in 11 patients (35.5%), neuropathy was in 19 patients (61.3%), and mesenchymopathy was in 10 patients (32.2%). An overlap between subtypes was observed in some cases. Surprisingly, the non\u2010dilated loop samples exhibited very similar histopathologic abnormalities to those observed in the dilated loop samples in most cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our study is the first to compare the histopathologic findings between dilated and non\u2010dilated loops in <jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content> patients. Histopathologic abnormalities precede the clinical manifestation of <jats:styled-content style=\"fixed-case\">IMC<\/jats:styled-content>, and may consequently lead to gradual colonic dilatation; however, detailed mechanism including dilation triggering factor needs further elucidation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12303","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T07:22:54Z","timestamp":1388992974000},"page":"571-580","source":"Crossref","is-referenced-by-count":18,"title":["Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non\u2010dilated loops"],"prefix":"10.1111","volume":"26","author":[{"given":"H.","family":"Ohkubo","sequence":"first","affiliation":[{"name":"Gastroenterology Division Yokohama City University School of Medicine Yokohama 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