{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:21:05Z","timestamp":1771071665676,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing evidence shows central abnormalities in functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) patients, but whether the symptom severity is directly reflected in altered brain patterns remains unclear. The purpose of this study was to explore how <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> affected the resting functional brain patterns for different degrees of symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional magnetic resonance imaging was carried out in 40 <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and 20 healthy controls. The resting\u2010state brain changes in regional homogeneity (ReHo) and seed correlation analysis were investigated in patients relative to controls. To what degree the brain changes reflected the severity of the disease was assessed by a pattern classification technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Altered ReHo values (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content> corrected) were discovered in multiple brain areas in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients, and only the anterior cingulate cortex (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) and thalamus exhibited significant correlation with the severity of dyspepsia symptoms. Compared with controls, the neural signal changes of the thalamus were not found in the less severe <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patient group but in the relatively more severe group, while the <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> showed aberrations in both groups. Seed\u2010based correlation analysis revealed <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>\u2010 and thalamus\u2010related functional connectivity differences between <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and controls at a voxel\u2010wise level, and the altered thalamic circuits provided the best performance in distinguishing <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients with different levels of symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our results indicated that the functional abnormalities of the <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> and thalamus may occur at different clinical courses in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. This may help us better understand the progression of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12311","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T08:52:44Z","timestamp":1390899164000},"page":"660-669","source":"Crossref","is-referenced-by-count":23,"title":["Altered intrinsic regional activity and corresponding brain pathways reflect the symptom severity of functional dyspepsia"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"Nan","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medical Central of the 181st Chinese People's Liberation Army Hospital Guilin Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Psychosomatic Medicine Department Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"von Deneen","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Liang","sequence":"additional","affiliation":[{"name":"The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology The Center for Medical Imaging Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2167-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.12.014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i25.3438"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21201"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.068"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.054"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02657.2000"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00562.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.39"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112819"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.086355"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156109.97999.d1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_1.i63"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.020"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.10"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1196"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.201"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.030"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.10.017"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.049"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000195666.22714.35"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20622"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.02.006"},{"key":"e_1_2_11_28_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J Gastrointest Liver"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00445.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3173"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01730060026004"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.081"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.02.016"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.042"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.116"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.019"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-194911000-00003"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.15222"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.07.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)49009-3"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01304.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70170-3"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90107-L"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.04.010"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.015"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.405"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.104"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:50:22Z","timestamp":1696236622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/nmo.12311"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12311","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}