{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:53:54Z","timestamp":1787741634190,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Measurements of anorectal function using high\u2010resolution anorectal manometry (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>) and rectal barostat technology provide more reliable results than standard <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> with an elastic balloon; however, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> results have not been compared to <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> and standard barostat protocols are impractical in routine clinical practice. The aim of this study was to validate <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> against standard <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> and standard barostat against a novel Rapid Barostat Bag (<jats:styled-content style=\"fixed-case\">RBB<\/jats:styled-content>) measurement and elastic balloon measurements of rectal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six healthy volunteers (15 female, 11 male, 19\u201352\u00a0years) were studied. Measurements of anal function and simulated defecation were compared for 12\u2010sensor <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> and 6\u2010sensor standard <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> using line plots from the same recording. Rectal capacity, compliance, and sensation (volume threshold) were measured by elastic balloon, standard barostat, and <jats:styled-content style=\"fixed-case\">RBB<\/jats:styled-content> methods using stepwise inflation of a 700\u2010mL polyethylene bag to 40\u00a0mmHg distension by electronic barostat and handheld syringe monitored by sphygmo\u2010manometer, respectively. Results are reported as mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>. Bland\u2013Altman plots and correlation coefficients (<jats:italic>r<\/jats:italic>) for measurements were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>There was excellent agreement between <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010 and standard <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> measurements (<jats:italic>r<\/jats:italic>\u00a0&gt;\u00a00.86, &lt;25\u00a0mmHg difference) and between standard barostat and <jats:styled-content style=\"fixed-case\">RBB<\/jats:styled-content> measurements of rectal capacity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.97, &lt;25\u00a0mL difference). Correlation coefficients of threshold volumes for initial perception, urgency and discomfort were 0.37, 0.71, and 0.95, respectively. No significant correlation was present with elastic balloon measurements. Time to complete studies was shorter for <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> than standard <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> and for <jats:styled-content style=\"fixed-case\">RBB<\/jats:styled-content> than standard barostat in historical controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">RBB<\/jats:styled-content> measurements of anorectal function provides quick and reasonably accurate measurements of continence function suitable for use in routine clinical practice (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrial.gov\">ClinicalTrial.gov<\/jats:ext-link> NCT01456442).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12317","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T11:29:53Z","timestamp":1392204593000},"page":"685-695","source":"Crossref","is-referenced-by-count":56,"title":["Toward more accurate measurements of anorectal motor and sensory function in routine clinical practice: Validation of High\u2010Resolution Anorectal Manometry and Rapid Barostat Bag measurements of rectal function"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Sauter","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"},{"name":"Department of Internal Medicine Triemli Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich 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