{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:04:27Z","timestamp":1765667067823,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK31369"],"award-info":[{"award-number":["R01 DK31369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 DK67674"],"award-info":[{"award-number":["R24 DK67674"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01 RR00046"],"award-info":[{"award-number":["M01 RR00046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acute intestinal infection leads to persistent intestinal smooth muscle hypercontractility and pain hypersensitivity after resolution of the infection in animal models. We investigated whether postinfectious irritable bowel syndrome (PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content>) is associated with abnormalities in phasic contractions of the colon, smooth muscle tone, and pain sensitivity compared to non\u2010PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> (NI<\/jats:styled-content>\u2010IBS<\/jats:styled-content>) or healthy controls (HC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Two hundred and eighteen Rome III\u2010positive IBS<\/jats:styled-content> patients and 43 HC<\/jats:styled-content> participated. IBS<\/jats:styled-content> patients were designated PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content>, if their IBS<\/jats:styled-content> symptoms began following an episode of gastroenteritis characterized by two or more of: fever, vomiting, or diarrhea. Pain threshold to phasic distentions of the descending colon was assessed using a barostat. Colonic motility was assessed with the barostat bag minimally inflated to the individual operating pressure (IOP<\/jats:styled-content>), at 20\u00a0mmHg above the IOP<\/jats:styled-content>, and following a test meal. IBS<\/jats:styled-content> symptom severity and psychological symptoms were assessed by the IBS<\/jats:styled-content> Severity Scale (IBS<\/jats:styled-content>\u2010SS<\/jats:styled-content>) and the Brief Symptom Inventory\u201018 (BSI<\/jats:styled-content>\u201018).<\/jats:p><\/jats:sec>Key Results<\/jats:title>Twenty two (10.1%) met criteria for PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content>. Both IBS<\/jats:styled-content> and HC<\/jats:styled-content> groups showed a significant increase in motility index during intraluminal distention and following meals. The magnitude of the response to distention above (orad to) the balloon was significantly greater in PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> compared with NI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> (p<\/jats:italic>\u00a0<\u00a00.05) or HC<\/jats:styled-content> (p<\/jats:italic>\u00a0<\u00a00.01). Differences between PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> and NI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> were not significant for IBS<\/jats:styled-content> symptom severity, pain threshold, barostat bag volumes, or any psychological score on the BSI<\/jats:styled-content>\u201018.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Patients with PI<\/jats:styled-content>\u2010IBS<\/jats:styled-content> have greater colonic hypercontractility than NI<\/jats:styled-content>\u2010IBS<\/jats:styled-content>. We speculate that sustained mild mucosal inflammation may cause this colonic irritability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12318","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T10:06:48Z","timestamp":1392286008000},"page":"696-704","source":"Crossref","is-referenced-by-count":16,"title":["Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI<\/scp>\u2010IBS<\/scp>)"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Behavioral Medicine Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A. L.","family":"van Tilburg","sequence":"additional","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Gangarosa","sequence":"additional","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fukudo","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii25"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.074"},{"key":"e_1_2_11_5_1","first-page":"307","article-title":"The irritable colon syndrome. 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