{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:39:03Z","timestamp":1762623543262},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although there is growing evidence that an increase in mucosal mast cells (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s) in the small and large intestine is associated with visceral hypersensitivity, few studies have evaluated <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s in humans with esophageal symptoms. The aim of this study was to investigate esophageal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> distribution in patients with non\u2010cardiac chest pain (<jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>) and to examine the association between the number of gut <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s and other functional gastrointestinal disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two consecutive <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content> patients and 10 healthy controls completed a questionnaire for bowel symptoms, chest pain intensity score, and psychologic depression. Esophageal, duodenal, and rectal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s were identified immunohistochemically and quantified by image analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Numbers of <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s were significantly higher in <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content> patients <jats:italic>vs<\/jats:italic> healthy controls (11.8\u00a0\u00b1\u00a05.6 <jats:italic>vs<\/jats:italic> 7.6\u00a0\u00b1\u00a03.7 <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>s\/high\u2010power field, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026). In comparison of subgroups classified by 24\u2010h impedance\u2013pH monitoring, esophageal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> counts were highest in the hypersensitive esophagus group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and were also significantly increased in the functional chest pain group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). A positive correlation between esophageal and duodenal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> counts was observed in patients with functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>; Spearman <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.604, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037). In particular, patients with clinical overlap with irritable bowel syndrome showed a strong positive correlation between esophageal and rectal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> numbers (Spearman <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.857, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Among <jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content> patients, increased <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> infiltration occurs in subgroups with hypersensitive esophagus and functional chest pain. In subpopulations with overlap with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> or irritable bowel syndrome, esophageal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> counts demonstrated significant positive correlations with duodenal or rectal <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> counts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12325","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:28:40Z","timestamp":1393262920000},"page":"786-793","source":"Crossref","is-referenced-by-count":17,"title":["Heterogeneity of mucosal mast cell infiltration in subgroups of patients with esophageal chest pain"],"prefix":"10.1111","volume":"26","author":[{"given":"H.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00787.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02175.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.2.110"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00685.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.194191"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302645"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12201"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802c0d06"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03366.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175810"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.04.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0594-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00733.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2000.00221.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04143.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.055"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.241307"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00873.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.469"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318299f181"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2005.02.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.039"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12080"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03937.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12245"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0045-1"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06249.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225521.36160.1b"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.104620"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.213108"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:48:08Z","timestamp":1696150088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/nmo.12325"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12325","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,21]]}}}