{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:12:59Z","timestamp":1788883979383,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Neurogenic inflammation involves vasodilation, oedema and sensory nerve hypersensitivity. Extrinsic sensory nerves to the intestinal wall mediate these effects and functional subsets of these extrinsic nerves can be characterized by immunohistochemical profiles. In this study such profiles were examined in samples from patients with inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ), in particular ulcerative colitis (\n UC<\/jats:styled-content>\n ) and\n C<\/jats:styled-content>\n rohn's disease (\n CD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Healthy margins from cancer patients were compared to specimens from\n IBD<\/jats:styled-content>\n patients. All nerve fibres were labelled by\n PGP<\/jats:styled-content>\n 9.5. Double and triple labelling with\n TH<\/jats:styled-content>\n ,\n NPY<\/jats:styled-content>\n ,\n SP<\/jats:styled-content>\n ,\n SOM<\/jats:styled-content>\n ,\n NOS<\/jats:styled-content>\n ,\n VIP<\/jats:styled-content>\n ,\n VAC<\/jats:styled-content>\n hT,\n CGRP<\/jats:styled-content>\n ,\n TRP<\/jats:styled-content>\n v1 were performed. Perivascular nerve fibres in the mesentery, and submucosa, were examined. The percentage of all labelled nerve fibres was calculated with a transect method.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Total number of varicosities on mesenteric vessels increased in\n IBD<\/jats:styled-content>\n but decreased around submucosal vessels. The percentage of nerve fibres around submucosal arteries labelled by\n SP<\/jats:styled-content>\n increased from 11% in controls to 20% (\n UC<\/jats:styled-content>\n ) and 24% (\n CD<\/jats:styled-content>\n ) and mesenteric artery nerve fibres were unchanged. Nerve fibres labelled by\n SOM<\/jats:styled-content>\n were markedly reduced surrounding submucosal arteries, from 22% to 1% (\n UC<\/jats:styled-content>\n ) and 2% (\n CD<\/jats:styled-content>\n ), but not perivascular mesenteric nerve fibres. 87 to 93% of\n SP<\/jats:styled-content>\n immunoreactive nerve fibres were also reactive for\n TR<\/jats:styled-content>\n vP1.\n TRP<\/jats:styled-content>\n v1 labelling without\n SP<\/jats:styled-content>\n was 12%in controls and increased to 40% in\n CD<\/jats:styled-content>\n submucosal specimens.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n There is an increase in\n SP<\/jats:styled-content>\n and\n TRP<\/jats:styled-content>\n v1, and a reduction in\n SOM<\/jats:styled-content>\n immunoreactive nerve fibres in\n IBD<\/jats:styled-content>\n . Changes in the perivascular functional nerve subclasses may underlie the hyperaemia, and ulceration, characteristic of\n IBD<\/jats:styled-content>\n . Furthermore, pain may relate to underlying neural changes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12327","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T23:02:43Z","timestamp":1394060563000},"page":"731-744","source":"Crossref","is-referenced-by-count":40,"title":["The neurochemical changes in the innervation of human colonic mesenteric and submucosal blood vessels in\n U<\/scp>\n lcerative colitis and\n C<\/scp>\n rohn's disease"],"prefix":"10.1111","volume":"26","author":[{"given":"D.","family":"de Fontgalland","sequence":"first","affiliation":[{"name":"Department of Surgery\/Department of Human Physiology Flinders Medical Centre\/Flinders University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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