{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:24:28Z","timestamp":1761017068049},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurophysiological evaluation of anorectal sensory function is hampered by a paucity of methods. Rapid balloon distension (<jats:styled-content style=\"fixed-case\">RBD<\/jats:styled-content>) has been introduced to describe the cerebral response to rectal distension, but it has not successfully been applied to the anal canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen healthy women received 30 <jats:styled-content style=\"fixed-case\">RBD<\/jats:styled-content>s in the rectum and the anal canal at intensities corresponding to sensory and unpleasantness thresholds, and response was recorded as cortical evoked potentials (<jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s) in 64\u2010channels. The anal canal stimulations at unpleasantness level were repeated after 4\u00a0min to test the within\u2010day reproducibility. <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s were averaged, and to overcome latency variation related to jitter the spectral content of single sweeps was also computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Repeated stimulation of the anal canal generated <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s with similar latencies but smaller amplitudes compared to those from the rectum. Due to latency jitter, reproducibility of averaged <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s was lower than what was found in the rectum. The most reproducible feature was N2P2 peak\u2010to\u2010peak amplitude with intra\u2010class correlation coefficient (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) of 0.7 and coefficient of variation (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) of 18%. Spectral content of the single sweeps showed reproducibility with <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>s for all bands &gt;0.8 and corresponding <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>s &lt;7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Cortical potentials evoked from the anal canal are challenged by latency jitter likely related to variability in muscle tone due to the distensions. Using single\u2010sweep analysis, anal <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s proved to be reproducible and should be used in future evaluation of the anal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12341","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T04:10:46Z","timestamp":1398053446000},"page":"862-873","source":"Crossref","is-referenced-by-count":13,"title":["Cortical evoked potentials in response to rapid balloon distension of the rectum and anal canal"],"prefix":"10.1111","volume":"26","author":[{"given":"S.","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brock","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital Aalborg Denmark"},{"name":"Center for Sensory\u2010Motor Interaction (SMI) Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gram","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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