{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:27:45Z","timestamp":1790965665122,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Bio & Medical Technology Development Program of the National Research Foundation","award":["2011-0019632"],"award-info":[{"award-number":["2011-0019632"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Anorectal manometry with simulated evacuation (\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      ) has limited applicability in predicting balloon expulsion (\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      ) test results. The newly developed high\u2010resolution anorectal manometry (\n                      <jats:styled-content style=\"fixed-case\">HRAM<\/jats:styled-content>\n                      ) technique can yield spatiotemporal plots with three\u2010dimensional pressurization. We aimed to define new parameters based on three\u2010dimensional integrated pressurized volume (\n                      <jats:styled-content style=\"fixed-case\">IPV<\/jats:styled-content>\n                      ) for predicting the\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      test results in asymptomatic normal individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four asymptomatic healthy individuals were prospectively enrolled.\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      tests were performed using 50\u00a0mL of water, and a requirement of more than 1\u00a0min was considered as delayed\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">HRAM<\/jats:styled-content>\n                      profiles were converted into\n                      <jats:styled-content style=\"fixed-case\">ASCII<\/jats:styled-content>\n                      files and analyzed using a\n                      <jats:styled-content style=\"fixed-case\">MATLAB<\/jats:styled-content>\n                      program. A three\u2010dimensional\n                      <jats:styled-content style=\"fixed-case\">IPV<\/jats:styled-content>\n                      was plotted after transforming the data to a cubic spline interpolation followed by resampling the manometry position at 0.1\u2010cm intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Eight of the 54 (15%) individuals demonstrated delayed\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      . Conventional manometric profiles did not differ significantly between cases of early and delayed\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      . Receiver\u2010operator characteristic curve analysis revealed that the ratio of the\n                      <jats:styled-content style=\"fixed-case\">IPV<\/jats:styled-content>\n                      s of the upper 1\u00a0cm to the lower 4\u00a0cm of the anorectal canal with balloon distension was more predictable of the\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      results (area under curve, 0.73: 95% confidence interval, 0.53\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) than the other\n                      <jats:styled-content style=\"fixed-case\">IPV<\/jats:styled-content>\n                      s or their ratios.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      The newly developed\n                      <jats:styled-content style=\"fixed-case\">IPV<\/jats:styled-content>\n                      methods could predict delayed\n                      <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>\n                      tests during\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      better than the conventional parameters defined on the basis of linear waves. Well\u2010designed prospective trials on a large number of subjects are warranted to validate the clinical application of this novel parameter.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12347","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T23:18:19Z","timestamp":1398295099000},"page":"937-949","source":"Crossref","is-referenced-by-count":23,"title":["A novel high\u2010resolution anorectal manometry parameter based on a three\u2010dimensional integrated pressurized volume of a spatiotemporal plot, for predicting balloon expulsion in asymptomatic normal individuals"],"prefix":"10.1111","volume":"26","author":[{"given":"Kee Wook","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul 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