{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:24:13Z","timestamp":1792034653702,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labour Sciences Research Grant for Research on Health Technology Assessment (Clinical Research Promotion No. 47 to HS) from the Ministry of Health, Labour and Welfare of Japan","award":["No.47"],"award-info":[{"award-number":["No.47"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rikkunshito, a standardized\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      apanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large\u2010scale, randomized, placebo\u2010controlled trials of rikkunshito have been conducted. This study aimed to determine the efficacy and safety of rikkunshito for treating functional dyspepsia (\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients received 2.5\u00a0g rikkunshito or placebo three times a day for 8\u00a0weeks in this multicenter, randomized, placebo\u2010controlled, parallel\u2010group trial. The primary end point was the proportion of responders at 8\u00a0weeks after starting test drug, determined by global patient assessment (\n                      <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                      ). The improvement in four major dyspepsia symptoms severity scale was also evaluated. In addition, plasma ghrelin levels were investigated before and after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Two hundred forty\u2010seven patients were randomly assigned. In the eighth week, the rikkunshito group had more\n                      <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>\n                      responders (33.6%) than the placebo (23.8%), although this did not reach statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.09). Epigastric pain was significantly improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) and postprandial fullness tended to improve (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06) in the rikkunshito group at week 8. Rikkunshito was relatively more effective among\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        elicobacter pylori\n                      <\/jats:italic>\n                      \u2010infected participants (rikkunshito: 40.0%\n                      <jats:italic>vs<\/jats:italic>\n                      placebo: 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07), and seemed less effective among\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        .\u00a0pylori\n                      <\/jats:italic>\n                      \u2010uninfected participants (rikkunshito: 29.3%\n                      <jats:italic>vs<\/jats:italic>\n                      placebo: 25.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.72). Among\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                        .\u00a0pylori\n                      <\/jats:italic>\n                      \u2010positive individuals, acyl ghrelin levels were improved just in rikkunshito group. There were no severe adverse events in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Administration of rikkunshito for 8\u00a0weeks reduced dyspepsia, particularly symptoms of epigastric pain and postprandial fullness. (\n                      <jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\n                      Clinical Trials Registry, Number UMIN000003954).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12348","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T04:48:22Z","timestamp":1398660502000},"page":"950-961","source":"Crossref","is-referenced-by-count":125,"title":["Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia\u2014a multicenter, double\u2010blind, randomized, placebo\u2010controlled study"],"prefix":"10.1111","volume":"26","author":[{"given":"H.","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo 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