{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:30Z","timestamp":1791489690591,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shire-Movetis NV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                      4 receptor agonist prucalopride is a prokinetic drug which improves colonic motility. Animal data and\n                      <jats:italic>in vitro<\/jats:italic>\n                      studies suggest that prucalopride also affects gastric and esophageal motor function. We aimed to assess the effect of prucalopride on gastric emptying, esophageal motility, and gastro\u2010esophageal reflux in man.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this double\u2010blind, placebo\u2010controlled, randomized, crossover study, we included 21 healthy volunteers who received 4\u00a0mg prucalopride or placebo per day for 6\u00a0days. We performed high\u2010resolution manometry (\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      ) followed by 120\u2010min\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      \u2010pH\u2010impedance monitoring after a standardized meal, ambulatory 24\u2010h pH\u2010impedance monitoring, and gastric emptying for solids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Prucalopride decreased (median [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ]) total acid exposure time (3.4 [2.5\u20135.6]\n                      <jats:italic>vs<\/jats:italic>\n                      1.7 [0.8\u20133.5] %,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The total number of reflux events was unaffected by prucalopride, however, the number of reflux events extending to the proximal esophagus was reduced by prucalopride (15.5 [9.8\u201325.5]\n                      <jats:italic>vs<\/jats:italic>\n                      10.5 [5.3\u201317.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Furthermore, prucalopride improved acid clearance time (77.5 [47.8\u2013108.8]\n                      <jats:italic>vs<\/jats:italic>\n                      44.0 [30.0\u201367.8] s,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Prucalopride did not affect the number of transient lower esophageal sphincter (\n                      <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>\n                      ) relaxations or their association with reflux events. Esophageal motility and basal pressure of the\n                      <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>\n                      were not affected by prucalopride. Prucalopride increased gastric emptying (T\n                      <jats:sub>1\/2<\/jats:sub>\n                      ; 32.7 [27.9\u201344.6]\n                      <jats:italic>vs<\/jats:italic>\n                      49.8 [37.7\u201355.0] min,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and decreased residue after 120\u00a0min (8.8 [4.4\u201314.8]\n                      <jats:italic>vs<\/jats:italic>\n                      2.7 [1.3\u20135.4] %,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>Prucalopride reduces esophageal acid exposure and accelerates gastric emptying in healthy male volunteers. These findings suggest that the drug could be effective for treatment of patients with reflux disease and functional dyspepsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12359","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:22:58Z","timestamp":1401322978000},"page":"1079-1086","source":"Crossref","is-referenced-by-count":122,"title":["Prucalopride decreases esophageal acid exposure and accelerates gastric emptying in healthy subjects"],"prefix":"10.1111","volume":"26","author":[{"given":"B. F.","family":"Kessing","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Bennink","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kraaijpoel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Oors","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04565.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00817.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018803129779"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/11204000-000000000-00000"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703985"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01087-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.682"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21166"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091226"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296657"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.3.246"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03090.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02968.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00854.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033290"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(09)62424-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03279.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074690"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02033.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.286"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12359","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:52:15Z","timestamp":1696261935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/nmo.12359"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12359","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,29]]}}}