{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:35:43Z","timestamp":1776893743826,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Q-Med \/ Oceana \/ Salix"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Injectable bulking treatment for fecal incontinence (\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      ) is intended to expand tissue in the anal canal and prevent fecal leakage. Use of injectable bulking agents is increasing because it can be performed in an outpatient setting and with low risk for morbidity. This study evaluated the long\u2010term (36\u2010month) clinical effectiveness and safety of injection of non\u2010animal stabilized hyaluronic acid\/dextranomer (\n                      <jats:styled-content style=\"fixed-case\">NASHA<\/jats:styled-content>\n                      Dx) on\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective multicenter trial, 136 patients with\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      received the\n                      <jats:styled-content style=\"fixed-case\">NASHA<\/jats:styled-content>\n                      Dx bulking agent. Treatment success defined as a reduction in number of\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      episodes by 50% or more compared with baseline (Responder\n                      <jats:sub>50<\/jats:sub>\n                      ). Change from baseline in Cleveland Clinic Florida Fecal Incontinence Score (\n                      <jats:styled-content style=\"fixed-case\">CCFIS<\/jats:styled-content>\n                      ) and Fecal Incontinence Quality of Life Scale (FIQL), and adverse events were also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Successful decrease in symptoms was achieved in 52% of patients at 6\u00a0months and this was sustained at 12\u00a0months (57%) and 36\u00a0months (52%). Mean\n                      <jats:styled-content style=\"fixed-case\">CCFIS<\/jats:styled-content>\n                      decreased from 14 at baseline to 11 at 36\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Quality\u2010of\u2010life scores for all four domains improved significantly between baseline and 36\u00a0months of follow\u2010up. Severe adverse events were rare and most adverse events were transient and pertained to minor bleeding and pain or discomfort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Submucosal injection of\n                      <jats:styled-content style=\"fixed-case\">NASHA<\/jats:styled-content>\n                      Dx provided a significant improvement of\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      symptoms in a majority of patients and this effect was stable during the course of the follow\u2010up and maintained for 3\u00a0years.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12360","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T02:30:57Z","timestamp":1400466657000},"page":"1087-1094","source":"Crossref","is-referenced-by-count":59,"title":["Long\u2010term efficacy of\n                    <scp>NASHA<\/scp>\n                    Dx injection therapy for treatment of fecal incontinence"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Mellgren","sequence":"first","affiliation":[{"name":"Division of Colon &amp; Rectal Surgery University of Illinois Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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