{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:43:57Z","timestamp":1770680637465,"version":"3.49.0"},"reference-count":73,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) is thought to be involved in dysregulation within the brain\u2013gut axis. Recently, altered striatum activation has been reported in patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. However, the gray matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) volumes in the striatum and structural covariance patterns of this area are rarely explored. The purpose of this study was to examine the <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes and structural covariance patterns of the striatum between <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T1\u2010weighted magnetic resonance images were obtained from 44 <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients and 39 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s. Voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) analysis was adopted to examine the <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes in the two groups. The caudate\u2010 or putamen\u2010related regions identified from <jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content> analysis were then used as seeds to map the whole brain voxel\u2010wise structural covariance patterns. Finally, a correlation analysis was used to investigate the effects of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> symptoms on the striatum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The results showed increased <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes in the bilateral putamen and right caudate. Compared with the structural covariance patterns of the <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s, the <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010related differences were mainly located in the amygdala, hippocampus\/parahippocampus (<jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>\/para<jats:styled-content style=\"fixed-case\">HIPP<\/jats:styled-content>), thalamus, lingual gyrus, and cerebellum. And significant positive correlations were found between the volumes in the striatum and the <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> duration in the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>These findings provided preliminary evidence for <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> changes in the striatum and different structural covariance patterns in patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. The current results might expand our understanding of the pathophysiology of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12372","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T04:22:44Z","timestamp":1401250964000},"page":"1144-1154","source":"Crossref","is-referenced-by-count":22,"title":["Altered structural covariance of the striatum in functional dyspepsia patients"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Liu","sequence":"first","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medical Central of the 181st People's Liberation Amy Hospital Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology The Center for Medical Imaging Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Liang","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012309-103958"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.078"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.10"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.39"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.405"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21201"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-2015-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90107-L"},{"key":"e_1_2_10_15_1","first-page":"386","article-title":"Functional anatomy of thalamus and basal ganglia","volume":"18","author":"Herrero M\u2010T","year":"2002","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007778"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0280-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007277107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.08.056"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.11.074"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr117"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws281"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26028-7"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06741.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.05.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05545.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.049"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35990"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405054038726"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00197"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq368"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.7.1049"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(08)70039-7"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0357-05.2005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.023"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003109107"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_10_40_1","first-page":"465","article-title":"Structural covariance in the hallucinating brain: a voxel\u2010based morphometry study","volume":"34","author":"Modinos G","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0422-5"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01363.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3173"},{"key":"e_1_2_10_44_1","first-page":"44","article-title":"Self\u2010rating anxiety scale (SAS)","volume":"2","author":"Wenyuan W","year":"1990","journal-title":"Shanghai Arch Psychol"},{"key":"e_1_2_10_45_1","first-page":"267","article-title":"Self\u2010rating depression Scale (SDS): an analysis on 1340 health subjects","volume":"12","author":"Chunfang W","year":"1986","journal-title":"Chin J Nerv Menl Dis"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20870"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.047"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010013\u20100657\u20109"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450701392282"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.052"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3687-09.2009"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0129-7"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295509.30630.10"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2819"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.029"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.02.005"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.05.010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.09.014"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.01.006"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02396-3"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01164-X"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20547"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.042"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.026"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj088"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00874.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.028514"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00008.x"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00720.x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892902760807212"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3536-06.2007"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858403261077"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068205"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:51:49Z","timestamp":1696276309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/nmo.12372"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12372","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}