{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:09Z","timestamp":1791309909812,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T00:00:00Z","timestamp":1400976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004388","name":"Cephalon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004388","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DRCI CHU de Grenoble"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autonomic dysfunction and mood disorders are frequently described in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) and are known to influence visceral sensitivity. We addressed the link between vagal tone, negative affect, and visceral sensitivity in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients without concomitant features of irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). Rectal distensions to a discomfort threshold of 70% and onset of pain were performed in nine <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients in remission and eight healthy controls. Autonomic parameters were evaluated with heart rate variability and electrodermal reactivity. We showed that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients had (i) higher scores of depressive symptomatology (12\u00a0\u00b1\u00a03 in patients <jats:italic>vs<\/jats:italic> 4\u00a0\u00b1\u00a01 in controls on the Center for Epidemiologic Studies\u2010Depression Scale; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), (ii) reduced vagal tone (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> 257\u00a0\u00b1\u00a084\u00a0ms<jats:sup>2<\/jats:sup> <jats:italic>vs<\/jats:italic> 1607\u00a0\u00b1\u00a01032\u00a0ms<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043; <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> 455\u00a0\u00b1\u00a0153\u00a0ms<jats:sup>2<\/jats:sup> <jats:italic>vs<\/jats:italic> 1629\u00a0\u00b1\u00a0585\u00a0ms<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047), (iii) decreased sympathetic reactivity during an aversive stimulus, and (iv) higher tolerance to rectal distension pressures (43\u00a0\u00b1\u00a03\u00a0mmHg <jats:italic>vs<\/jats:italic> 30\u00a0\u00b1\u00a02\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and low sensitivity index scores. In conclusion, our results provide preliminary evidence that patients with quiescent <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, in the absence of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, are hyposensate to experimental rectal distension. These data provide further evidence that anxiety and depressive symptomatology in addition to autonomic dysfunction modulate visceral pain perception in quiescent <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients in the absence of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/nmo.12373","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T02:55:13Z","timestamp":1401072913000},"page":"1200-1203","source":"Crossref","is-referenced-by-count":34,"title":["The link between negative affect, vagal tone, and visceral sensitivity in quiescent <scp>C<\/scp>rohn's disease"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Rubio","sequence":"first","affiliation":[{"name":"INSERM, U836 Grenoble France"},{"name":"Univ. Grenoble Alpes, GIN Grenoble France"},{"name":"CHU de Grenoble H\u00f4pital Couple Enfants Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pellissier","sequence":"additional","affiliation":[{"name":"INSERM, U836 Grenoble France"},{"name":"Univ. Grenoble Alpes, GIN Grenoble France"},{"name":"Univ. Savoie Chambery France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Picot","sequence":"additional","affiliation":[{"name":"CHU de Grenoble H\u00f4pital Michallon Clinique Universitaire d'H\u00e9patogastroent\u00e9rologie Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dantzer","sequence":"additional","affiliation":[{"name":"Univ. Savoie Chambery France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bonaz","sequence":"additional","affiliation":[{"name":"INSERM, U836 Grenoble France"},{"name":"Univ. Grenoble Alpes, GIN Grenoble France"},{"name":"CHU de Grenoble H\u00f4pital Michallon Clinique Universitaire d'H\u00e9patogastroent\u00e9rologie Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05475.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.10.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01493.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.260"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02007.x"},{"key":"e_1_2_9_7_1","first-page":"1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use","volume":"5","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","year":"1996","journal-title":"Circulation"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00150-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-7-33"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.10.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03062-X"},{"key":"e_1_2_9_13_1","volume-title":"Adaptation\u2010Level Theory: An Experimental and Systematic Approach to Behavior","author":"Helson H","year":"1964"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198520110-00008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00047-4"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12373","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:52:18Z","timestamp":1696276338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,25]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/nmo.12373"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12373","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,25]]}}}