{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:36:29Z","timestamp":1776893789212,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Symptom relief in functional gastrointestinal disorders (<jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>) is frequently sought with complementary and alternative medicine, and various herbal medicine compounds are popular in different parts of the world. Only a few products, however, are standardized and are backed by scientific evidence. This review mainly focuses on mechanistic and clinical data in support of the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese traditional compound Rikkunshi\u2010to (<jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content>) and of <jats:styled-content style=\"fixed-case\">STW<\/jats:styled-content>\u20105. Their effects on gut sensori\u2010motor function, neurohormonal network, and controlled clinical data in <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content> are revised. <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">STW<\/jats:styled-content>\u20105 appear to possess some degree of gastroprokinetic, visceral analgesic properties, and seem to increase the gastric accommodation response. Controlled trials of <jats:styled-content style=\"fixed-case\">RKT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">STW<\/jats:styled-content>\u20105 support at least a modest effect on symptoms of functional dyspepsia and irritable bowel syndrome, with low side effects profile. With the widespread use of herbals and the relative paucity of effective pharmacological options for <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>, rigorous studies to further elucidate pharmacological actions and clinical applications of herbal compounds are a priority.<\/jats:p>","DOI":"10.1111\/nmo.12384","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T08:04:10Z","timestamp":1403769850000},"page":"893-900","source":"Crossref","is-referenced-by-count":26,"title":["Standardized herbal treatments on functional bowel disorders: moving from putative mechanisms of action to controlled clinical trials"],"prefix":"10.1111","volume":"26","author":[{"given":"F.","family":"Cremonini","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Southern Nevada VA Healthcare System Las Vegas NV USA"},{"name":"Las Vegas Gastroenterology and First Class Medicine Las Vegas NV 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