{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:12:43Z","timestamp":1773454363324,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T00:00:00Z","timestamp":1403481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK92179 and DK67071"],"award-info":[{"award-number":["DK92179 and DK67071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>\n<jats:italic>Background<\/jats:italic>\n<\/jats:title><jats:p><jats:italic>There have been significant advances in understanding the pathophysiological mechanisms in patients with neurogastroenterological disorders including irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) and functional abdominal pain, functional diarrhea, chronic constipation, gastroparesis, and functional dyspepsia. These advances have led to the development of novel pharmacological therapy of neurogastroenterological disorders<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:italic>Purpose<\/jats:italic>\n<\/jats:title><jats:p><jats:italic>To review peer\u2010reviewed articles or prominent preliminary communications presented in the past year regarding medications in development for functional gastrointestinal disorders or gastroparesis. The medications fall into two main categories: first, established classes of medications within established classes, such as 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 receptor antagonists and 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>4 receptor agonists, and second, new classes of medications such as a combined \u03bc\u2010opioid agonist and \u03b4\u2010antagonist, or a small molecule ghrelin agonist<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12386","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T05:41:09Z","timestamp":1403588469000},"page":"1070-1078","source":"Crossref","is-referenced-by-count":19,"title":["Novel therapeutic agents in neurogastroenterology: advances in the past year"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Camilleri","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) 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