{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:57Z","timestamp":1790517477790,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K23DK084113"],"award-info":[{"award-number":["5K23DK084113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Functional gastrointestinal disorders (\n FGID<\/jats:styled-content>\n ) patients report poor health\u2010related quality of life (\n HRQOL<\/jats:styled-content>\n ) and experience high rates of psychiatric and extraintestinal functional disorder (\n EIFD<\/jats:styled-content>\n ) comorbidity. The independent influence of these comorbidities on\n HRQOL<\/jats:styled-content>\n and symptom burden remains unknown. We sought to determine whether\n FGID<\/jats:styled-content>\n with mood or\n EIFD<\/jats:styled-content>\n comorbidity have poorer\n HRQOL<\/jats:styled-content>\n and greater\n GI<\/jats:styled-content>\n symptom burdens; to determine the influence of comorbidities on\n HRQOL<\/jats:styled-content>\n in\n FGID<\/jats:styled-content>\n independent of bowel symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Subjects reported on comorbidities (anxiety, depression, somatization,\n EIFD<\/jats:styled-content>\n ),\n FGID<\/jats:styled-content>\n criteria (irritable bowel syndrome,\n IBS<\/jats:styled-content>\n ; functional dyspepsia,\n FD<\/jats:styled-content>\n ) using\n ROME<\/jats:styled-content>\n III Research questionnaire,\n GI<\/jats:styled-content>\n symptom burden, and\n HRQOL<\/jats:styled-content>\n . Differences in measures were assessed between subjects with and without\n ROME<\/jats:styled-content>\n III criteria. Multiple regression determined the relative contribution of comorbidities to\n HRQOL<\/jats:styled-content>\n , and mediation analysis explored whether comorbidity influences\n HRQOL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n In a cohort of 912\n GI<\/jats:styled-content>\n outpatients (47.2\u00a0\u00b1\u00a01.5\u00a0years, 75.8% female), 606 (66.4%) met Rome III\n IBS<\/jats:styled-content>\n and\/or\n FD<\/jats:styled-content>\n criteria. Comorbidities were common in\n FGID<\/jats:styled-content>\n (\u22651 in 77.4%), leading to lower\n HRQOL<\/jats:styled-content>\n and greater\n GI<\/jats:styled-content>\n symptom burden (each\n p<\/jats:italic>\n \u00a0<\u00a00.05). Poorer\n HRQOL<\/jats:styled-content>\n was predicted by both psychiatric and\n EIFD<\/jats:styled-content>\n comorbidity (each\n p<\/jats:italic>\n \u00a0<\u00a00.05) independent of\n GI<\/jats:styled-content>\n symptoms (\n p<\/jats:italic>\n \u00a0<\u00a00.001). Comorbidities together exerted a greater effect on predicted variation in\n HRQOL<\/jats:styled-content>\n (70.9%) relative to\n GI<\/jats:styled-content>\n symptoms (26.5%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n Psychiatric and\n EIFD<\/jats:styled-content>\n comorbidities are common in\n FGID<\/jats:styled-content>\n , decrease\n HRQOL<\/jats:styled-content>\n and are associated with greater\n GI<\/jats:styled-content>\n symptom burdens; these factors were stronger predictors of\n HRQOL<\/jats:styled-content>\n than\n GI<\/jats:styled-content>\n symptoms in\n FGID<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12396","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T03:07:11Z","timestamp":1406603231000},"page":"1323-1332","source":"Crossref","is-referenced-by-count":73,"title":["The impact of psychiatric and extraintestinal comorbidity on quality of life and bowel symptom burden in functional\n GI<\/scp>\n disorders"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"Vu","sequence":"first","affiliation":[{"name":"Saint Louis University St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cassell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. P.","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Sayuk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Psychiatry Washington University School of Medicine St. Louis Missouri USA"},{"name":"John Cochran Veterans Affairs Medical Center Saint Louis University St. Louis Missouri 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