{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:49:53Z","timestamp":1785527393729,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Norgine Ltd","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Most methods of assessing colonic motility are poorly acceptable to patients. Magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) can monitor gastrointestinal motility and fluid distributions. We predicted that a dose of oral polyethylene glycol (\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      ) and electrolyte solution would increase ileo\u2010colonic inflow and stimulate colonic motility. We aimed to investigate the colonic response to distension by oral\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      electrolyte in healthy volunteers (\n                      <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\n                      s) and to evaluate the effect of single 2\u00a0L\n                      <jats:italic>vs<\/jats:italic>\n                      split (2\u00a0\u00d7\u00a01\u00a0L) dosing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twelve\n                      <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\n                      s received a split dose (1\u00a0L the evening before and 1\u00a0L on the study day) and another 12\n                      <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\n                      s a single dose (2\u00a0L on the main study day) of\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      electrolyte. They underwent\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      scans, completed symptom questionnaires, and provided stool samples. Outcomes included small bowel water content, ascending colon motility index, and regional colonic volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Small bowel water content increased fourfold from baseline after ingesting both split (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0010) and single dose (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0005). The total colonic volume increase from baseline was smaller for the split dose at 35\u00a0\u00b1\u00a08% than for the single dose at 102\u00a0\u00b1\u00a027%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0332. The ascending colon motility index after treatment was twofold higher for the single dose group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0103).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Ingestion of 1 and 2\u00a0L\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      electrolyte solution caused a rapid increase in the small bowel and colonic volumes and a robust rise in colonic motility. The increase in both volumes and motility was dose dependent. Such a challenge, being well\u2010tolerated, could be a useful way of assessing colonic motility in future studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12403","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T23:23:05Z","timestamp":1406244185000},"page":"1426-1436","source":"Crossref","is-referenced-by-count":46,"title":["Stimulation of colonic motility by oral\n                    <scp>PEG<\/scp>\n                    electrolyte bowel preparation assessed by\n                    <scp>MRI<\/scp>\n                    : comparison of split\n                    <i>vs<\/i>\n                    single dose"],"prefix":"10.1111","volume":"26","author":[{"given":"L.","family":"Marciani","sequence":"first","affiliation":[{"name":"Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Garsed","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Hoad","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fields","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fordham","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Placidi","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chaddock","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Costigan","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lam","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jalanka\u2010Tuovinen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"De Vos","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences University of Helsinki Helsinki Finland"},{"name":"Laboratory of Microbiology Wageningen University Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Gowland","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Magnetic Resonance Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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