{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:37:38Z","timestamp":1778686658579,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan.","doi-asserted-by":"crossref","award":["NSC 101-2314-B-303-005-MY3"],"award-info":[{"award-number":["NSC 101-2314-B-303-005-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The transient receptor potential vanilloid 1 has been implicated as a target mediator for heartburn perception and modulation of esophageal secondary peristalsis. Our aim was to determine the effect of repeated esophageal infusion of capsaicin\u2010contained red pepper sauce on heartburn perception and secondary peristalsis in healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary peristalsis was performed with mid\u2010esophageal injections of air in 15 healthy adults. Two separate protocols including esophageal infusion with saline and capsaicin\u2010contained red pepper sauce and 2 consecutive sessions of capsaicin\u2010contained red pepper sauce were randomly performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>After repeated infusion of capsaicin\u2010contained red pepper sauce, the threshold volume to activate secondary peristalsis was significantly increased during slow (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and rapid air injections (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). Acute infusion of capsaicin\u2010contained red pepper sauce enhanced heartburn perception (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), but the intensity of heartburn perception was significantly reduced after repeated capsaicin\u2010contained red pepper sauce infusion (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). Acute infusion of capsaicin\u2010contained red pepper sauce significantly increased pressure wave amplitudes of distal esophagus during slow (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) and rapid air injections (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), but repeated infusion of capsaicin\u2010contained red pepper sauce significantly decreased pressure wave amplitude of distal esophagus during slow (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005) and rapid air injections (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Repeated esophageal infusion of capsaicin appears to attenuate heartburn perception and inhibit distension\u2010induced secondary peristalsis in healthy adults. These results suggest capsaicin\u2010sensitive afferents in modulating sensorimotor function of secondary peristalsis in human esophagus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12414","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T03:16:46Z","timestamp":1408072606000},"page":"1487-1493","source":"Crossref","is-referenced-by-count":11,"title":["Influence of repeated infusion of capsaicin\u2010contained red pepper sauce on esophageal secondary peristalsis in humans"],"prefix":"10.1111","volume":"26","author":[{"given":"T. T.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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